Vyas Yelda, Salkar Akanksha, Bothale A Kalpana
Consultant Pathologist, Dr. Lal Path Labs, Nagpur, Maharashtra, India.
Consultant Pathologist, Care Hospital, Hyderabad, Telangana, India.
Indian J Pathol Microbiol. 2018 Jul-Sep;61(3):434-436. doi: 10.4103/IJPM.IJPM_591_17.
We report a rare case of an 83-year-old male with synchronous occurrence of prostate adenocarcinoma and multiple myeloma. He presented with lower back pain and incontinence of urine for the past 6 months. Routine hematological and biochemical investigations were performed which pointed toward prostate adenocarcinoma. Transrectal ultrasonography and magnetic resonance imaging showed prostatomegaly along with osteolytic lesions in the skull and vertebrae. Prostate biopsy was performed and adenocarcinoma was confirmed. To rule out metastatic deposits in the bone and to rule out bone marrow infiltration, bone marrow aspiration and biopsy of the patient was done, and unexpectedly, it showed multiple myeloma. The association between these two disorders is poorly understood, but some studies show that bone marrow microenvironment plays an important role.
我们报告了一例罕见病例，一名83岁男性同时患有前列腺腺癌和多发性骨髓瘤。他在过去6个月中出现下背部疼痛和尿失禁。进行了常规血液学和生化检查，结果指向前列腺腺癌。经直肠超声检查和磁共振成像显示前列腺肿大，同时颅骨和椎骨有溶骨性病变。进行了前列腺活检，确诊为腺癌。为排除骨转移灶和骨髓浸润，对该患者进行了骨髓穿刺和活检，出乎意料的是，结果显示为多发性骨髓瘤。这两种疾病之间的关联尚不清楚，但一些研究表明骨髓微环境起着重要作用。
