Fridkin Gil, Columbus Ishay, Yehezkel Lea, Zafrani Yossi
Department of Organic Chemistry , Israel Institute for Biological Research , Ness-Ziona 74100 , Israel.
J Org Chem. 2018 Sep 7;83(17):10541-10545. doi: 10.1021/acs.joc.8b01314. Epub 2018 Jul 24.
Solvent effects on the ability of KF/AlO supports to degrade the warfare agent sulfur mustard (HD) were explored. RP-KF/AlO possessing hydroxide ions and ECUF/KF/AlO holding fluoride ions were examined. Reactions on RP-KF/AlO containing 10 wt % of organic solvents were faster than those on ECUF/KF/AlO. Additionally, RP-KF/AlO led to elimination products, while ECUF/KF/AlO mainly led to substitution derivatives. Enlarging the solvent amounts to 90 wt % resulted in decreased reaction rates. The significance of solvent identity/amount and active species is discussed.
研究了溶剂对KF/AlO载体降解战争毒剂芥子气（HD）能力的影响。考察了含有氢氧根离子的RP-KF/AlO和含有氟离子的ECUF/KF/AlO。在含有10 wt%有机溶剂的RP-KF/AlO上的反应比在ECUF/KF/AlO上的反应更快。此外，RP-KF/AlO产生消除产物，而ECUF/KF/AlO主要产生取代衍生物。将溶剂量增加到90 wt%导致反应速率降低。讨论了溶剂种类/用量和活性物种的重要性。
