Garcia Raymond L, McCullough Jerry L, Reece Barry, Massino Frank J
J Drugs Dermatol. 2018 Jul 1;17(7):772-779.
To evaluate the efficacy and tolerance of topical 4HBAP (para-topolin [6-(4-hydroxybenzylamino) purine], a new aromatic cytokinin, in subjects with mild to moderate facial photodamage.
In this single-center, 12-week study subjects (n=39) applied topical 0.10% 4HBAP (the test article) and sunblock (SPF30) twice daily, in the early morning and in the evening. The efficacy and safety of the treatment were evaluated at study entry (baseline) and at 2, 4, 8 and 12 weeks. Results were evaluated by investigators and subjects using high resolution photography and objectively by transepidermal water loss (skin barrier function), and a Novameter® (skin moisture content).
Topical 4HBAP significantly improved the appearance of coarse wrinkles after 4, 8, and 12 weeks of continued use without irritating the skin or eliciting erythema. Topical 4HBAP also improved the appearance of fine wrinkles, hyperpigmentation, and skin roughness while significantly reducing facial erythema and the overall severity of acne lesions. The investigators global assessment, the overall severity of skin aging and skin color, showed significant improvement at weeks 8 and 12. Subject-assessed improvements were also highly favorable. In the 25 subjects that had acne at baseline, the number of non-inflammatory lesions and the total number of acne lesions decreased significantly at weeks 8 and 12. Topical 4HBAP significantly increased skin hydration at weeks 2, 8, and 12.
Topical 4HBAP (0.10%) significantly improves the appearance of fine lines and coarse wrinkles, reduces skin roughness, hyperpigmentation, facial erythema, and non-inflammatory acne lesions, and improves skin hydration without any observed side effects. J Drugs Dermatol. 2018;17(7):772-779.
评估局部应用4HBAP（对-托普林[6-(4-羟基苄氨基)嘌呤]，一种新型芳香族细胞分裂素）治疗轻至中度面部光损伤患者的疗效及耐受性。
在这项为期12周的单中心研究中，39名受试者每天早晚两次局部应用0.10% 4HBAP（受试药物）和防晒霜（防晒指数30）。在研究开始时（基线）以及第2、4、8和12周评估治疗的疗效和安全性。研究人员和受试者通过高分辨率摄影评估结果，同时通过经表皮水分流失（皮肤屏障功能）和Novameter®（皮肤水分含量）进行客观评估。
持续使用4、8和12周后，局部应用4HBAP可显著改善粗大皱纹外观，且不刺激皮肤或引起红斑。局部应用4HBAP还可改善细小皱纹、色素沉着和皮肤粗糙外观，同时显著减轻面部红斑和痤疮皮损的总体严重程度。研究人员的整体评估，即皮肤老化和肤色的总体严重程度，在第8周和第12周时显示出显著改善。受试者评估的改善情况也非常良好。在基线时有痤疮的25名受试者中，非炎性皮损数量和痤疮皮损总数在第8周和第12周时显著减少。局部应用4HBAP在第2、8和12周时显著增加皮肤水合作用。
局部应用0.10% 4HBAP可显著改善细纹和粗大皱纹外观，减轻皮肤粗糙、色素沉着、面部红斑和非炎性痤疮皮损，并改善皮肤水合作用，且未观察到任何副作用。《药物皮肤病学杂志》。2018年；17(7):772 - 779。
