商业个人护理产品混合物对青海弧菌 Q67 表现出兴奋浓度反应。
Commercial personal care product mixtures exhibit hormetic concentration-responses to Vibrio qinghaiensis sp.-Q67.
机构信息
State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.
State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China.
出版信息
Ecotoxicol Environ Saf. 2018 Oct 30;162:304-311. doi: 10.1016/j.ecoenv.2018.07.007. Epub 2018 Jul 11.
The biological effects related to personal care products (PCPs) are almost induced by some active ingredients in the PCPs rather than the PCP itself. In this study, 23 common and widely used toner, skin water, and make-up water (TSM) commodities were directly taken as mixture samples, and Vibrio qinghaiensis sp.-Q67 (Q67) was used as the test organism. The toxicities of the TSMs to Q67 were determined via microplate toxicity analysis at 0.25 h and 12 h. Each TSM commodity can be regarded as a complicated mixture (relative concentration is 1). It was shown that the concentration-response curves (CRCs) of 23 TSMs are monotonic sigmoid-shaped (S-shaped) at 0.25 h, the CRCs of six TSMs are also S-shaped but the other 17 TSMs are non-monotonic hormetic or J-shaped at 12 h. In addition, to effectively characterize the nature of the stimulation and inhibition phases, it is suggested that five parameters such as the EC (the median stimulation effective concentration (left)), E (the maximum stimulation effect), EC (the maximum stimulation effective concentration), ZEP (zero effect point where the effect is 0 and the concentration is ZEP), and EC can depict the non-monotonic CRC. To the best of our knowledge, this is the first study about the hormetic CRCs of commercial PCP mixtures.
个人护理产品（PCP）相关的生物学效应几乎都是由 PCP 中的某些活性成分引起的，而不是 PCP 本身。在本研究中，我们直接将 23 种常见且广泛使用的爽肤水、化妆水作为混合物样品，并选用青海弧菌（Q67）作为测试生物。通过微孔板毒性分析，在 0.25 小时和 12 小时时，测定了 TSM 对 Q67 的毒性。每个 TSM 商品都可以看作是一种复杂的混合物（相对浓度为 1）。结果表明，在 0.25 小时时，23 种 TSM 的浓度-反应曲线（CRC）均为单调的 S 型，6 种 TSM 的 CRC 也是 S 型，但另外 17 种 TSM 的 CRC 是非单调的兴奋或 J 型。此外，为了有效描述刺激和抑制阶段的性质，建议使用五个参数，如 EC（左为刺激有效浓度的中位数）、E（最大刺激效果）、EC（最大刺激有效浓度）、ZEP（效应为 0 且浓度为 ZEP 的零效应点）和 EC，来描述非单调的 CRC。据我们所知，这是首次研究商业 PCP 混合物的兴奋 CRC。
Zotero 插件