Tomita T, Friesen S R, Kimmel J R
Cancer. 1986 Jan 1;57(1):129-33. doi: 10.1002/1097-0142(19860101)57:1<129::aid-cncr2820570126>3.0.co;2-q.
A case of documented pancreatic polypeptide (PP)-secreting islet cell tumor was followed for 3 years and 8 months until death due to multiple metastases. The patient initially presented with extremely high serum PP levels without clinical symptoms. After resection of the PP-secreting islet cell tumor, serum PP levels gradually decreased to normal levels. Serum PP levels started to elevate 10 months after the surgery, when liver metastases were verified by open biopsy. The patient was treated with streptozotocin (STZ), and normal serum PP levels returned. However, multiple liver and bone metastases were detected 32 months after resection of the tumor, which led to death. The recurrent tumor obtained at autopsy contained very little immunoreactive PP. The effect of STZ on PP secretion by the islet cell tumor is discussed.
一例有记录的分泌胰多肽（PP）的胰岛细胞瘤患者被随访了3年8个月，直至因多发转移而死亡。患者最初血清PP水平极高但无临床症状。切除分泌PP的胰岛细胞瘤后，血清PP水平逐渐降至正常水平。术后10个月，经开放活检证实有肝转移时，血清PP水平开始升高。患者接受链脲佐菌素（STZ）治疗后，血清PP水平恢复正常。然而，肿瘤切除后32个月检测到多发肝转移和骨转移，最终导致患者死亡。尸检获得的复发肿瘤中免疫反应性PP含量极少。文中讨论了STZ对胰岛细胞瘤PP分泌的影响。
