Zucker Hillside Hospital, 75-59 263rd Street, Glen Oaks, NY 11004, USA.
Zucker Hillside Hospital, 75-59 263rd Street, Glen Oaks, NY 11004, USA; Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA; Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Boulevard, Hempstead, NY 11549, USA.
Schizophr Res. 2018 Dec;202:26-36. doi: 10.1016/j.schres.2018.07.013. Epub 2018 Jul 11.
Improving quality of life for people with first episode psychosis is an important aspect of recovery. Our objective was to review the associative factors on quality of life in first episode psychosis. A meta-analysis was conducted on the associations between quality of life, symptom severity, and duration of untreated psychosis.
Fifty-one articles were identified (published through 08/29/2016) that provided data on the relationship between quality of life and at least one other outcome measure of interest in first episode psychosis. Of those studies, 21 were included in a meta-analysis (n = 3992) of the relationship between quality of life, severity of psychosis, and duration of untreated psychosis.
Meta-analysis identified significant negative correlations between quality of life and severity of symptoms (total symptom scores: r = -0.32, p < 0.001) and quality of life and duration of untreated psychosis (r = -0.21, p < 0.001). Heinrich's quality of life scale emerged as being more sensitive to the presence of psychotic symptoms than other measures of quality of life.
Associations were found between certain disease specific variables and quality of life in first episode psychosis, highlighting the relationship between symptom presentation and quality of life and the need for early intervention. Proper assessment of quality of life is important to promote improved quality of life in patients with first episode psychosis. Future research is needed to examine the interacting effects of symptom presentation, duration of untreated psychosis, and other variables, such as neurocognition, on quality of life.
提高首发精神病患者的生活质量是康复的一个重要方面。我们的目的是综述首发精神病患者生活质量的相关影响因素。我们对生活质量与精神病症状严重程度和未治疗精神病持续时间之间的关联进行了荟萃分析。
共确定了 51 篇文章（发表于 2016 年 8 月 29 日之前），这些文章提供了首发精神病患者生活质量与至少一项其他感兴趣的结局指标之间关系的数据。在这些研究中，21 项研究（n=3992）的生活质量、精神病严重程度和未治疗精神病持续时间之间的关系被纳入荟萃分析。
荟萃分析确定生活质量与精神病症状严重程度（总分：r=-0.32，p<0.001）和生活质量与未治疗精神病持续时间（r=-0.21，p<0.001）之间存在显著负相关。Heinrich 生活质量量表比其他生活质量测量方法更能反映出精神病症状的存在。
首发精神病患者的某些特定疾病变量与生活质量之间存在关联，突出了症状表现与生活质量之间的关系以及早期干预的必要性。对生活质量进行适当评估对于提高首发精神病患者的生活质量非常重要。未来的研究需要检验症状表现、未治疗精神病持续时间以及神经认知等其他变量对生活质量的交互影响。
