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本文引用的文献

1
Induction of CD4 T cell memory by local cellular collectivity.通过局部细胞群体诱导 CD4 T 细胞记忆。
Science. 2018 Jun 15;360(6394). doi: 10.1126/science.aaj1853.
2
Organ-level quorum sensing directs regeneration in hair stem cell populations.器官水平的群体感应指导毛囊干细胞群体的再生。
Cell. 2015 Apr 9;161(2):277-90. doi: 10.1016/j.cell.2015.02.016.
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Macrophages and therapeutic resistance in cancer.巨噬细胞与癌症治疗耐药性
Cancer Cell. 2015 Apr 13;27(4):462-72. doi: 10.1016/j.ccell.2015.02.015. Epub 2015 Apr 6.
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Single-cell RNA-seq reveals dynamic paracrine control of cellular variation.单细胞 RNA 测序揭示了细胞变异的动态旁分泌控制。
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Quorum sensing contributes to activated IgM-secreting B cell homeostasis.群体感应有助于激活的 IgM 分泌 B 细胞的稳态。
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Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell.CTLA-4 通过激活 Hippo 通路调节 CD8+T 细胞中 Blimp-1 的表达。
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Bacterial quorum-sensing network architectures.细菌群体感应网络架构
Annu Rev Genet. 2009;43:197-222. doi: 10.1146/annurev-genet-102108-134304.
8
Variability and robustness in T cell activation from regulated heterogeneity in protein levels.蛋白质水平调控异质性导致的T细胞激活中的变异性和稳健性。
Science. 2008 Aug 22;321(5892):1081-4. doi: 10.1126/science.1158013.
9
Culture at high density improves the ability of human macrophages to control mycobacterial growth.高密度培养可提高人类巨噬细胞控制分枝杆菌生长的能力。
J Immunol. 2001 May 15;166(10):6203-11. doi: 10.4049/jimmunol.166.10.6203.
10
Cell density-dependent expression of chondroitin sulfate proteoglycan in cultured human monocytes.培养的人单核细胞中硫酸软骨素蛋白聚糖的细胞密度依赖性表达
J Biol Chem. 1988 Feb 15;263(5):2526-31.

免疫系统中的群体感应。

Quorum sensing in the immune system.

机构信息

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Laboratory of Cardiovascular Physiology and Tissue Injury, National Institutes of Health/NIAAA, Bethesda, MD, USA.

出版信息

Nat Rev Immunol. 2018 Sep;18(9):537-538. doi: 10.1038/s41577-018-0040-4.

DOI:10.1038/s41577-018-0040-4
PMID:30006523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6202123/
Abstract

Quorum sensing is the regulation of gene expression programmes in response to changes in population density. It is probably best recognized as a mechanism through which bacterial communities can synchronize behaviours, such as biofilm formation and bioluminescence. This Comment article highlights the emerging evidence suggesting that quorum sensing also contributes to the regulation of immune cell responses.

摘要

群体感应是一种根据种群密度变化来调节基因表达程序的机制。它可能是一种使细菌群落能够同步行为的机制,例如生物膜的形成和生物发光。本文评论强调了越来越多的证据表明,群体感应也有助于调节免疫细胞的反应。