免疫系统中的群体感应。
Quorum sensing in the immune system.
机构信息
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Laboratory of Cardiovascular Physiology and Tissue Injury, National Institutes of Health/NIAAA, Bethesda, MD, USA.
出版信息
Nat Rev Immunol. 2018 Sep;18(9):537-538. doi: 10.1038/s41577-018-0040-4.
Abstract
Quorum sensing is the regulation of gene expression programmes in response to changes in population density. It is probably best recognized as a mechanism through which bacterial communities can synchronize behaviours, such as biofilm formation and bioluminescence. This Comment article highlights the emerging evidence suggesting that quorum sensing also contributes to the regulation of immune cell responses.
摘要
群体感应是一种根据种群密度变化来调节基因表达程序的机制。它可能是一种使细菌群落能够同步行为的机制，例如生物膜的形成和生物发光。本文评论强调了越来越多的证据表明，群体感应也有助于调节免疫细胞的反应。
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1
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2
Organ-level quorum sensing directs regeneration in hair stem cell populations.器官水平的群体感应指导毛囊干细胞群体的再生。
Cell. 2015 Apr 9;161(2):277-90. doi: 10.1016/j.cell.2015.02.016.
3
Macrophages and therapeutic resistance in cancer.巨噬细胞与癌症治疗耐药性
Cancer Cell. 2015 Apr 13;27(4):462-72. doi: 10.1016/j.ccell.2015.02.015. Epub 2015 Apr 6.
4
Single-cell RNA-seq reveals dynamic paracrine control of cellular variation.单细胞 RNA 测序揭示了细胞变异的动态旁分泌控制。
Nature. 2014 Jun 19;510(7505):363-9. doi: 10.1038/nature13437. Epub 2014 Jun 11.
5
Quorum sensing contributes to activated IgM-secreting B cell homeostasis.群体感应有助于激活的 IgM 分泌 B 细胞的稳态。
J Immunol. 2013 Jan 1;190(1):106-14. doi: 10.4049/jimmunol.1200907. Epub 2012 Dec 3.
6
Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell.CTLA-4 通过激活 Hippo 通路调节 CD8+T 细胞中 Blimp-1 的表达。
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7
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8
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9
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10
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J Biol Chem. 1988 Feb 15;263(5):2526-31.
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