Service of Therapeutic Education for Chronic Diseases, WHO Collaborating Centre, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.
Unit of Population Epidemiology, Department of Community Medicine, Primary Care and Emergency Medicine, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland.
Int J Obes (Lond). 2019 May;43(5):1120-1124. doi: 10.1038/s41366-018-0150-x. Epub 2018 Jul 13.
Exogenous oxytocin administration in obese mice, rats, and monkeys was shown to induce sustained weight loss, mostly due to a decrease in fat mass, accompanied by an improvement of glucose metabolism. A pilot study in obese humans confirmed the weight-reducing effect of oxytocin. Knowledge about circulating oxytocin levels in human obesity might help indicating which obese subjects could potentially benefit from an oxytocin treatment. Conclusive results on this topic are missing. The aim of this study was to measure circulating oxytocin levels in lean (n = 37) and obese (n = 72) individuals across a wide range of body mass index (BMI) values (18.5-60 kg/m) and to determine the impact of pronounced body weight loss following gastric bypass surgery in 12 morbidly obese patients. We observed that oxytocin levels were unchanged in overweight and in class I and II obese subjects and only morbidly obese patients (obesity class III, BMI > 40 kg/m) exhibited significantly higher levels than lean individuals, with no modification 1 year after gastric bypass surgery, despite substantial body weight loss. In conclusion, morbidly obese subjects present elevated oxytocin levels which were unaltered following pronounced weight loss.
外源性催产素在肥胖小鼠、大鼠和猴子中的给药显示可诱导持续的体重减轻，主要是由于脂肪量减少，同时改善葡萄糖代谢。在肥胖人群中的一项初步研究证实了催产素的减重作用。关于人类肥胖症中循环催产素水平的知识可能有助于指示哪些肥胖患者可能受益于催产素治疗。关于这个主题的结论性结果尚不清楚。本研究的目的是测量在广泛的体重指数（BMI）值（18.5-60kg/m）范围内的瘦（n=37）和肥胖（n=72）个体中的循环催产素水平，并确定胃旁路手术后 12 名病态肥胖患者明显体重减轻的影响。我们观察到，超重和 I 级和 II 级肥胖患者的催产素水平没有变化，只有病态肥胖患者（肥胖症 III 级，BMI >40kg/m）的水平明显高于瘦个体，并且在胃旁路手术后 1 年没有改变，尽管体重明显减轻。总之，病态肥胖患者表现出升高的催产素水平，在明显体重减轻后没有改变。
