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Oxytocin mRNA is expressed throughout the small intestine in individuals with and without type 2 diabetes, and circulating neurophysin I declines after Roux-en-Y gastric bypass surgery.

作者信息

Gether Ida M, Gilliam-Vigh Hannah, Kliim-Hansen Vivian, Hartmann Bolette, Holst Jens J, Lund Asger B, Gasbjerg Lærke S, Knop Filip K

机构信息

Center for Clinical Metabolic Research, Copenhagen University Hospital - Herlev and Gentofte, Hellerup, Denmark.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

出版信息

Diabetes Obes Metab. 2025 Sep;27(9):5373-5377. doi: 10.1111/dom.16571. Epub 2025 Jul 2.

DOI:10.1111/dom.16571
PMID:40600482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12326935/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f867/12326935/7b09e6f71f99/DOM-27-5373-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f867/12326935/7b09e6f71f99/DOM-27-5373-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f867/12326935/7b09e6f71f99/DOM-27-5373-g001.jpg

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本文引用的文献

1
Neurophysin I is an analytically robust surrogate biomarker for oxytocin.神经垂体素 I 是一种分析上稳健的催产素替代生物标志物。
Psychoneuroendocrinology. 2024 Mar;161:106951. doi: 10.1016/j.psyneuen.2023.106951. Epub 2023 Dec 30.
2
Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling.微生物通过分泌素信号刺激肠上皮细胞释放催产素。
Gut Microbes. 2023 Dec;15(2):2256043. doi: 10.1080/19490976.2023.2256043.
3
Serum Oxytocin Levels Decrease 12 Months Following Sleeve Gastrectomy and Are Associated with Decreases in Lean Mass.
血清催产素水平在袖状胃切除术后 12 个月下降，与瘦体重减少相关。
Int J Mol Sci. 2023 Jun 14;24(12):10144. doi: 10.3390/ijms241210144.
4
Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery.Roux-en-Y 胃旁路手术后肠道黏膜基因表达和代谢变化。
Obesity (Silver Spring). 2020 Nov;28(11):2163-2174. doi: 10.1002/oby.22973.
5
Metabolic Effects of Oxytocin.催产素的代谢作用。
Endocr Rev. 2020 Apr 1;41(2):121-45. doi: 10.1210/endrev/bnz012.
6
Circulating Oxytocin Is Genetically Determined and Associated With Obesity and Impaired Glucose Tolerance.循环催产素受遗传决定，与肥胖和葡萄糖耐量受损有关。
J Clin Endocrinol Metab. 2019 Nov 1;104(11):5621-5632. doi: 10.1210/jc.2019-00643.
7
Variable oxytocin levels in humans with different degrees of obesity and impact of gastric bypass surgery.肥胖程度不同的人群中催产素水平的变化及胃旁路手术的影响。
Int J Obes (Lond). 2019 May;43(5):1120-1124. doi: 10.1038/s41366-018-0150-x. Epub 2018 Jul 13.
8
Decreased circulating levels of oxytocin in obesity and newly diagnosed type 2 diabetic patients.肥胖和新诊断的 2 型糖尿病患者循环中催产素水平降低。
J Clin Endocrinol Metab. 2014 Dec;99(12):4683-9. doi: 10.1210/jc.2014-2206.
9
The use of double-balloon enteroscopy in retrieving mucosal biopsies from the entire human gastrointestinal tract.双气囊小肠镜在获取全人类胃肠道黏膜活检组织中的应用。
Scand J Gastroenterol. 2014 Sep;49(9):1143-9. doi: 10.3109/00365521.2014.934912. Epub 2014 Jul 7.
10
Oxytocin is expressed throughout the human gastrointestinal tract.催产素在整个人类胃肠道中均有表达。
Regul Pept. 2006 Jul 15;135(1-2):7-11. doi: 10.1016/j.regpep.2006.03.008. Epub 2006 May 5.