Centre for Inflammation Biology and Cancer Immunology (CIBCI), Department of Inflammation Biology, School of Immunology & Microbial Sciences, King's College London, London, UK.
Department of Rheumatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Nat Rev Rheumatol. 2018 Aug;14(8):453-466. doi: 10.1038/s41584-018-0044-2.
Spondyloarthritis (SpA) is a term that refers to a group of inflammatory diseases that includes psoriatic arthritis, axial SpA and nonradiographic axial SpA, reactive arthritis, enteropathic arthritis and undifferentiated SpA. The disease subtypes share clinical and immunological features, including joint inflammation (peripheral and axial skeleton); skin, gut and eye manifestations; and the absence of diagnostic autoantibodies (seronegative). The diseases also share genetic factors. The aetiology of SpA is still the subject of research by many groups worldwide. Evidence from genetic, experimental and clinical studies has accumulated to indicate a clear role for the IL-17 pathway in the pathogenesis of SpA. The IL-17 family consists of IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F, of which IL-17A is the best studied. IL-17A is a pro-inflammatory cytokine that also has the capacity to promote angiogenesis and osteoclastogenesis. Of the six family members, IL-17A has the strongest homology with IL-17F. In this Review, we discuss how IL-17A and IL-17F and their cellular sources might contribute to the immunopathology of SpA.
脊柱关节炎（SpA）是一组炎症性疾病的统称，包括银屑病关节炎、中轴型 SpA 和非放射学中轴型 SpA、反应性关节炎、肠病性关节炎和未分化 SpA。这些疾病亚型具有共同的临床和免疫学特征，包括关节炎症（外周和中轴骨骼）；皮肤、肠道和眼部表现；以及缺乏诊断自身抗体（血清阴性）。这些疾病还具有遗传因素。SpA 的病因仍然是全球许多研究小组研究的课题。遗传、实验和临床研究的证据表明，IL-17 通路在 SpA 的发病机制中起着明确的作用。IL-17 家族包括 IL-17A、IL-17B、IL-17C、IL-17D、IL-17E 和 IL-17F，其中 IL-17A 研究得最多。IL-17A 是一种促炎细胞因子，也具有促进血管生成和破骨细胞生成的能力。在这六个家族成员中，IL-17A 与 IL-17F 的同源性最强。在这篇综述中，我们讨论了 IL-17A 和 IL-17F 及其细胞来源如何导致 SpA 的免疫病理学。
