富马酸二甲酯诱导的 IL-17 IFN-γ IL-4 Th 细胞保护小鼠免受严重的脑脊髓炎。
Dimethyl fumarate-induced IL-17 IFN-γ IL-4 Th cells protect mice from severe encephalomyelitis.
机构信息
Department of Dermatology, University Medical Center, Eberhard Karls University Tübingen, Tübingen, Germany.
出版信息
Eur J Immunol. 2018 Sep;48(9):1588-1591. doi: 10.1002/eji.201747435. Epub 2018 Aug 22.
PMID:30007005
Abstract
Dimethyl fumarate (DMF) promotes an IL-17A IFN-γ IL-4 CD4 T cell phenotype. Adoptive transfer of in vitro DMF-treated myelin peptide-reactive IL-17A IFN-γ IL-4 CD4 T cells prior to immunization for EAE reduces the severity of encephalomyelitis. This beneficial effect of transferred DMF-treated CD4 T cells requires an early in vivo recall.
摘要
富马酸二甲酯（DMF）促进 IL-17A IFN-γ IL-4 CD4 T 细胞表型。在 EAE 免疫前，体外 DMF 处理的髓鞘肽反应性 IL-17A IFN-γ IL-4 CD4 T 细胞过继转移可降低脑脊髓炎的严重程度。转移的 DMF 处理的 CD4 T 细胞的这种有益作用需要早期体内回忆。
Zotero 插件