Huang J S, Huang S S
Ciba Found Symp. 1985;116:46-65. doi: 10.1002/9780470720974.ch4.
Cellular genes which encode proteins involved in the response of cells to stimulation by growth factors may be potential oncogenes. The factors involved in the signal transmission from growth factor-receptor interaction to DNA synthesis constitute a cascade system which we call the 'growth factor-proto-oncogene pathway(s) of mitogenesis'. For each growth factor, all the responsive cells, regardless of cell types and tissue source, have specific growth factor receptors which are similar, if not identical, in molecular weight and biological activity. Thus, we believe that the growth factor-proto-oncogene pathway(s) functions in the same manner in all responsive cells. Platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and brain-derived growth factor (BDGF) are major growth factors for connective tissue cells and do not share a common pathway in mitogenesis in responsive cells. The gene product of c-myc may be involved in the cellular response of cells stimulated by PDGF or FGF, but not directly in the signal transmission which leads to DNA synthesis.
编码参与细胞对生长因子刺激反应的蛋白质的细胞基因可能是潜在的癌基因。从生长因子 - 受体相互作用到DNA合成的信号传递过程中涉及的因子构成了一个级联系统，我们称之为“有丝分裂的生长因子 - 原癌基因途径”。对于每种生长因子，所有反应性细胞，无论细胞类型和组织来源如何，都有特定的生长因子受体，其分子量和生物学活性即使不完全相同也相似。因此，我们认为生长因子 - 原癌基因途径在所有反应性细胞中以相同方式起作用。血小板衍生生长因子（PDGF）、表皮生长因子（EGF）和脑衍生生长因子（BDGF）是结缔组织细胞的主要生长因子，在反应性细胞的有丝分裂中不共享共同途径。c - myc的基因产物可能参与由PDGF或FGF刺激的细胞的细胞反应，但不直接参与导致DNA合成的信号传递。
