抗体形成中的遗传控制与细胞相互作用。

Genetic controls and cellular interactions in antibody formation.

作者信息

Katz D H

出版信息

Hosp Pract. 1977 Feb;12(2):85-99. doi: 10.1080/21548331.1977.11707080.

DOI:10.1080/21548331.1977.11707080

Abstract

Both thymus-derived lymphocytes (T cells) and bone marrow--derived lymphocytes (B cells) play critical roles in specific antibody responses to antigens. Genetic controls of the antibody response in mammals have been found to reside largely within the major histocompatibility complex where different genes appear to code for immune response (Ir), immune suppression (Is), and cell interaction (CI) molecules.

摘要

胸腺衍生淋巴细胞（T细胞）和骨髓衍生淋巴细胞（B细胞）在针对抗原的特异性抗体反应中均发挥关键作用。已发现哺乳动物抗体反应的遗传控制主要存在于主要组织相容性复合体中，其中不同基因似乎编码免疫反应（Ir）、免疫抑制（Is）和细胞相互作用（CI）分子。