促肾上腺皮质激素对大鼠下丘脑体外释放促肾上腺皮质激素释放因子的抑制作用。
Inhibitory effect of adrenocorticotropin on corticotropin- releasing factor release from rat hypothalamus in vitro.
作者信息
Suda T, Yajima F, Tomori N, Sumitomo T, Nakagami Y, Ushiyama T, Demura H, Shizume K
出版信息
Endocrinology. 1986 Jan;118(1):459-61. doi: 10.1210/endo-118-1-459.
Effects of ACTH and ACTH fragments on immunoreactive corticotropin-releasing factor (I-CRF) release were examined by utilizing rat hypothalamic perifusion system and a rat CRF RIA. ACTH-(1-39) had a dose-related inhibitory effect on I-CRF release. Mean percent inhibition of I-CRF release was 52, 55, 49, 30 and less than 5 percent by ACTH-(1-39), ACTH-(1-24), alpha-MSH and ACTH-(18-39) at 2.2 nM concentrations, respectively. These results suggest the presence of a negative short-loop feedback mechanism, and also that the active core is contained within the ACTH-(1-17) structure.
通过使用大鼠下丘脑灌流系统和大鼠促肾上腺皮质激素释放因子放射免疫分析法（rat CRF RIA），研究了促肾上腺皮质激素（ACTH）及其片段对免疫反应性促肾上腺皮质激素释放因子（I-CRF）释放的影响。促肾上腺皮质激素-（1-39）对I-CRF释放具有剂量相关的抑制作用。在2.2 nM浓度下，促肾上腺皮质激素-（1-39）、促肾上腺皮质激素-（1-24）、α-促黑素（alpha-MSH）和促肾上腺皮质激素-（18-39）对I-CRF释放的平均抑制百分比分别为52%、55%、49%、30%和小于5%。这些结果表明存在负性短环反馈机制，并且活性核心包含在促肾上腺皮质激素-（1-17）结构内。
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