Washington University Brown School of Public Health, St. Louis, MO.
Washington University Brown School of Public Health, St. Louis, MO; Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO.
Clin Breast Cancer. 2018 Oct;18(5):e997-e1002. doi: 10.1016/j.clbc.2018.06.013. Epub 2018 Jun 27.
Male breast cancer is rare and understudied compared with female breast cancer. A current comparison with female breast cancer could assist in bridging this gap. Although conflicting data have been reported on male and female survival outcomes, data from 1973 through 2005 in the Surveillance, Epidemiology, and End Results (SEER) program have demonstrated that the improvement in breast cancer survival in men has fallen behind that of women. As treatment for breast cancer has improved significantly, an updated analysis using a contemporary population is necessary.
An analysis of SEER data from patients with a diagnosis of primary breast cancer from 2005 to 2010 were included. A Cox regression model was used to examine the association between sex and breast cancer mortality after controlling for prognostic factors, including age, race, marital status, disease stage, estrogen and progesterone receptor status, lymph node involvement, tumor grade, surgery, and geography. Subgroup analyses were performed by race and stage.
We included a total of 289,673 breast cancer cases (2054 men) with a diagnosis from 2005 to 2010. The 5-year survival rate for male patients was lower than that for female patients (82.8% vs. 88.5%). After controlling for other factors, the risk of death in men was 43% greater than that in women during the follow-up period (hazard ratio, 1.43; 95% confidence interval, 1.26-1.61). Similar results were noted in the race and stage subgroup analyses.
In recent years, male breast cancer patients have had worse survival outcomes compared with those of female patients.
与女性乳腺癌相比，男性乳腺癌较为罕见，研究也较少。目前对男性乳腺癌与女性乳腺癌进行比较，可以帮助弥补这一差距。尽管男性和女性的生存结果报告的数据存在冲突，但 1973 年至 2005 年期间监测、流行病学和最终结果（SEER）计划的数据表明，男性乳腺癌生存率的提高已经落后于女性。由于乳腺癌的治疗已经有了显著的改善，因此使用当代人群进行更新的分析是必要的。
分析了 2005 年至 2010 年期间诊断为原发性乳腺癌的 SEER 数据。使用 Cox 回归模型，在控制年龄、种族、婚姻状况、疾病分期、雌激素和孕激素受体状态、淋巴结受累、肿瘤分级、手术和地理位置等预后因素的情况下，检验了性别与乳腺癌死亡率之间的关联。还进行了种族和分期的亚组分析。
我们共纳入了 289673 例（男性 2054 例）在 2005 年至 2010 年间诊断为乳腺癌的患者。男性患者的 5 年生存率低于女性患者（82.8%比 88.5%）。在控制了其他因素后，男性在随访期间死亡的风险比女性高 43%（风险比，1.43；95%置信区间，1.26-1.61）。在种族和分期的亚组分析中也观察到了类似的结果。
近年来，男性乳腺癌患者的生存结果比女性患者差。
