血栓素类似物U46619对犬气道胆碱能神经传递的调节作用
Modulation of cholinergic neurotransmission in canine airways by thromboxane mimetic U46619.
作者信息
Chung K F, Evans T W, Graf P D, Nadel J A
出版信息
Eur J Pharmacol. 1985 Nov 19;117(3):373-5. doi: 10.1016/0014-2999(85)90012-3.
We studied the effect of a thromboxane A2-mimetic, U46619, on the contractile responses of canine bronchial smooth muscle to cholinergic stimulation in vitro. U46619 (3 X 10(-10) M), at a concentration that did not cause contraction, enhanced the effect of electrical field stimulation at all frequencies; histamine (10(-7) M) and prostaglandin F2 alpha (10(-7) M) did not. U46619 (3 X 10(-10) M) did not affect methacholine-induced contractions. U46619 may therefore increase the prejunctional release of acetylcholine.
我们在体外研究了血栓素A2模拟物U46619对犬支气管平滑肌对胆碱能刺激的收缩反应的影响。U46619（3×10⁻¹⁰ M）在不引起收缩的浓度下，增强了所有频率的电场刺激的作用；组胺（10⁻⁷ M）和前列腺素F2α（10⁻⁷ M）则没有。U46619（3×10⁻¹⁰ M）不影响乙酰甲胆碱诱导的收缩。因此，U46619可能会增加乙酰胆碱的节前释放。
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