1Laboratory of Molecular Psychiatry,Hospital de Clínicas de Porto Alegre (HCPA) and Programa de Pós-graduação em Psiquiatria e Ciências do Comportamento,Faculdade de Medicina,Universidade Federal do Rio Grande do Sul (UFRGS),Porto Alegre,Brazil.
2Graduation Program in Health Sciences,State University of Londrina (UEL),Londrina,Brazil.
Acta Neuropsychiatr. 2018 Dec;30(6):334-341. doi: 10.1017/neu.2018.13. Epub 2018 Jul 16.
This study aimed to explore effects of adjunctive treatment with N-acetyl cysteine (NAC) on markers of inflammation and neurogenesis in bipolar depression.
This is a secondary analysis of a placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, and week 32 of the open-label and maintenance phases of the clinical trial to determine changes in interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-α (TNF-α), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following adjunctive NAC treatment, and to explore mediation and moderator effects of the listed markers.
Levels of brain-derived neurotrophic factor (BDNF), tumour necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukins (IL) -6, 8, or 10 were not significantly changed during the course of the trial or specifically in the open-label and maintenance phases. There were no mediation or moderation effects of the biological factors on the clinical parameters.
The results suggest that these particular biological parameters may not be directly involved in the therapeutic mechanism of action of adjunctive NAC in bipolar depression.
本研究旨在探讨辅助治疗 N-乙酰半胱氨酸（NAC）对双相抑郁炎症和神经发生标志物的影响。
这是一项安慰剂对照随机试验的二次分析。在临床试验的开放标签和维持阶段的基线、第 8 周和第 32 周采集血清样本，以确定辅助 NAC 治疗后白细胞介素（IL）-6、IL-8、IL-10、肿瘤坏死因子-α（TNF-α）、C 反应蛋白（CRP）和脑源性神经营养因子（BDNF）的变化，并探讨列出的标志物的中介和调节作用。
在试验过程中或在开放标签和维持阶段，脑源性神经营养因子（BDNF）、肿瘤坏死因子-α（TNF-α）、C 反应蛋白（CRP）、白细胞介素（IL）-6、8 或 10 的水平均无明显变化。生物学因素对临床参数没有中介或调节作用。
结果表明，这些特定的生物学参数可能与辅助 NAC 在双相抑郁中的治疗作用机制没有直接关系。
