• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

膨胀床吸附的数学建模——计算机模拟过程设计的视角

Mathematical modelling of expanded bed adsorption - a perspective on in silico process design.

作者信息

Koppejan Victor, Ferreira Guilherme, Lin Dong-Qiang, Ottens Marcel

机构信息

Delft University of Technology Department of Biotechnology, Van der Maasweg 9, 2629 HZ Delft The Netherlands.

DSM Biotechnology Center Center of Integrated BioProcessing, Alexander Fleminglaan 1 2613 AX Delft The Netherlands.

出版信息

J Chem Technol Biotechnol. 2018 Jul;93(7):1815-1826. doi: 10.1002/jctb.5595. Epub 2018 Apr 6.

DOI:10.1002/jctb.5595
PMID:30008502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6032964/
Abstract

Expanded bed adsorption (EBA) emerged in the early 1990s in an attempt to integrate the clarification, capture and initial product concentration/purification process. Several mathematical models have been put forward to describe its operation. However, none of the models developed specifically for EBA allows simultaneous prediction of bed hydrodynamics, mass transfer/adsorption and (unwanted) interactions and fouling. This currently limits the development and early optimization of EBA-based separation processes. In multiphase reactor engineering, the use of multiphase computational fluid dynamics has been shown to improve fundamental understanding of fluidized beds. To advance EBA technology, a combination of particle, equipment and process scale models should be used. By employing a cascade of multiscale simulations, the various challenges EBA currently faces can be addressed. This allows for optimal design and selection of equipment, materials and process conditions, and reduces risks and development times of downstream processes involving EBA. © 2018 The Authors. published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

摘要

扩张床吸附（EBA）于20世纪90年代初出现，旨在整合澄清、捕获和初始产物浓缩/纯化过程。已经提出了几种数学模型来描述其操作。然而，专门为EBA开发的模型都无法同时预测床层流体动力学、传质/吸附以及（不需要的）相互作用和污垢。这目前限制了基于EBA的分离过程的开发和早期优化。在多相反应器工程中，多相计算流体动力学的应用已被证明能增进对流化床的基本理解。为了推进EBA技术，应结合使用颗粒、设备和过程尺度模型。通过采用一系列多尺度模拟，可以应对EBA目前面临的各种挑战。这有助于对设备、材料和工艺条件进行优化设计和选择，并降低涉及EBA的下游工艺的风险和开发时间。© 2018作者。由John Wiley & Sons Ltd代表化学工业协会出版。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/2d6bd099abf6/JCTB-93-1815-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/4b540c50d6cd/JCTB-93-1815-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/55f1354b71a1/JCTB-93-1815-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/c752c0872c1e/JCTB-93-1815-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/728bc8485eaa/JCTB-93-1815-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/0ad3618a880d/JCTB-93-1815-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/57fd75a23e33/JCTB-93-1815-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/255ccf912f01/JCTB-93-1815-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/f9730c7daf78/JCTB-93-1815-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/3d996ecbbbfc/JCTB-93-1815-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/e93ba174925b/JCTB-93-1815-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/358cf4312ee9/JCTB-93-1815-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/2d6bd099abf6/JCTB-93-1815-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/4b540c50d6cd/JCTB-93-1815-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/55f1354b71a1/JCTB-93-1815-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/c752c0872c1e/JCTB-93-1815-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/728bc8485eaa/JCTB-93-1815-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/0ad3618a880d/JCTB-93-1815-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/57fd75a23e33/JCTB-93-1815-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/255ccf912f01/JCTB-93-1815-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/f9730c7daf78/JCTB-93-1815-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/3d996ecbbbfc/JCTB-93-1815-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/e93ba174925b/JCTB-93-1815-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/358cf4312ee9/JCTB-93-1815-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e9/6032964/2d6bd099abf6/JCTB-93-1815-g013.jpg

相似文献

1
Mathematical modelling of expanded bed adsorption - a perspective on in silico process design.膨胀床吸附的数学建模——计算机模拟过程设计的视角
J Chem Technol Biotechnol. 2018 Jul;93(7):1815-1826. doi: 10.1002/jctb.5595. Epub 2018 Apr 6.
2
Clarification and capture of high-concentration refold pools for E. coli-based therapeutics using expanded bed adsorption chromatography.使用扩展床吸附层析技术对大肠杆菌基治疗药物进行高浓度复性液的澄清和捕获。
Biotechnol Prog. 2014 Jan-Feb;30(1):113-23. doi: 10.1002/btpr.1833. Epub 2013 Nov 13.
3
Direct coupling of expanded bed adsorption with a downstream purification step.膨胀床吸附与下游纯化步骤的直接耦合。
Bioseparation. 1999;8(1-5):201-7.
4
Antibody capture from corn endosperm extracts by packed bed and expanded bed adsorption.通过填充床和扩张床吸附从玉米胚乳提取物中捕获抗体。
Biotechnol Prog. 2005 Mar-Apr;21(2):473-85. doi: 10.1021/bp049689s.
5
Minimising biomass/adsorbent interactions in expanded bed adsorption processes: a methodological design approach.在膨胀床吸附过程中最小化生物质/吸附剂相互作用：一种方法学设计方法。
Bioseparation. 2001;10(1-3):7-19. doi: 10.1023/a:1012091031567.
6
Modeling of scale-down effects on the hydrodynamics of expanded bed adsorption columns.缩小规模对膨胀床吸附柱流体动力学影响的建模。
Biotechnol Bioeng. 2003 Mar 30;81(7):790-9. doi: 10.1002/bit.10522.
7
On-line purification of monoclonal antibodies using an integrated stirred-tank reactor/expanded-bed adsorption system.使用集成搅拌罐反应器/扩张床吸附系统对单克隆抗体进行在线纯化。
Biotechnol Prog. 2002 Nov-Dec;18(6):1292-300. doi: 10.1021/bp025543m.
8
Predictive modeling of protein adsorption along the bed height by taking into account the axial nonuniform liquid dispersion and particle classification in expanded beds.通过考虑膨胀床中轴向非均匀液体分散和颗粒分级来预测沿床高的蛋白质吸附。
J Chromatogr A. 2005 Nov 18;1095(1-2):16-26. doi: 10.1016/j.chroma.2005.07.120. Epub 2005 Aug 18.
9
Ion exchange purification of G6PDH from unclarified yeast cell homogenates using expanded bed adsorption.使用扩张床吸附从未澄清的酵母细胞匀浆中进行离子交换纯化葡萄糖-6-磷酸脱氢酶。
Biotechnol Bioeng. 1996 Jan 20;49(2):204-16. doi: 10.1002/(SICI)1097-0290(19960120)49:2<204::AID-BIT9>3.0.CO;2-U.
10
Fabrication and evaluation of low-cost agarose-zinc nanoporous composite matrix: influence of adsorbent density and size distribution on the performance of expanded beds.低成本琼脂糖-锌纳米多孔复合基质的制备与评价：吸附剂密度和粒径分布对膨胀床性能的影响。
J Chromatogr A. 2012 Sep 28;1257:89-97. doi: 10.1016/j.chroma.2012.08.022. Epub 2012 Aug 13.

引用本文的文献

1
Simulation of Adsorption Process of l-Tryptophan on Mixed-Mode Resin HD-1 with Combined Physical Adsorption and Ion Exchange.L-色氨酸在兼具物理吸附和离子交换功能的混合模式树脂HD-1上的吸附过程模拟
ACS Omega. 2022 Sep 25;7(39):35331-35338. doi: 10.1021/acsomega.2c05194. eCollection 2022 Oct 4.

本文引用的文献

1
Evaluation and characterization of axial distribution in expanded bed: II. Liquid mixing and local effective axial dispersion.膨胀床轴向分布的评估与表征：II. 液体混合与局部有效轴向扩散
J Chromatogr A. 2015 May 8;1393:65-72. doi: 10.1016/j.chroma.2015.03.019. Epub 2015 Mar 14.
2
Purifying biopharmaceuticals: knowledge-based chromatographic process development.生物制药的纯化：基于知识的色谱过程开发。
Trends Biotechnol. 2014 Apr;32(4):210-20. doi: 10.1016/j.tibtech.2014.02.001. Epub 2014 Mar 11.
3
Evaluating two process scale chromatography column header designs using CFD.
使用计算流体动力学（CFD）评估两种制备规模色谱柱头设计。
Biotechnol Prog. 2014 Jul-Aug;30(4):837-44. doi: 10.1002/btpr.1902. Epub 2014 Mar 19.
4
Evaluation and characterization of axial distribution in expanded bed. I. Bead size, bead density and local bed voidage.膨胀床轴向分布的评价与表征。I. 粒径、珠体密度和局部床层空隙率。
J Chromatogr A. 2013 Aug 23;1304:78-84. doi: 10.1016/j.chroma.2013.06.057. Epub 2013 Jul 1.
5
Experimental characterization of next-generation expanded-bed adsorbents for capture of a recombinant protein expressed in high-cell-density yeast fermentation.用于捕获在高细胞密度酵母发酵中表达的重组蛋白的下一代扩张床吸附剂的实验表征
Biotechnol Appl Biochem. 2013 Sep-Oct;60(5):510-20. doi: 10.1002/bab.1133. Epub 2013 Oct 1.
6
Modeling of ion exchange expanded-bed chromatography for the purification of C-phycocyanin.离子交换膨胀床色谱法用于纯化 C-藻蓝蛋白的建模。
J Chromatogr A. 2013 Mar 15;1281:73-8. doi: 10.1016/j.chroma.2013.01.081. Epub 2013 Jan 25.
7
Surface modification of chromatography adsorbents by low temperature low pressure plasma.低温低压等离子体对色谱吸附剂的表面改性。
J Chromatogr A. 2010 Oct 29;1217(44):6905-16. doi: 10.1016/j.chroma.2010.08.069. Epub 2010 Sep 23.
8
Effect of chemical additives on biomass deposition onto beaded adsorbents.化学添加剂对珠状吸附剂上生物质沉积的影响。
J Biosci Bioeng. 2010 Nov;110(5):564-71. doi: 10.1016/j.jbiosc.2010.06.006. Epub 2010 Jul 4.
9
Mathematical modeling and simulation of inulinase adsorption in expanded bed column.菊粉酶在膨胀床柱中吸附的数学建模与模拟
J Chromatogr A. 2009 May 15;1216(20):4395-401. doi: 10.1016/j.chroma.2009.03.027. Epub 2009 Mar 17.
10
Preparation and evaluation of polymer-coated adsorbents for the expanded bed recovery of protein products from particulate feedstocks.用于从颗粒原料中膨胀床回收蛋白质产品的聚合物包覆吸附剂的制备与评价
J Chromatogr A. 2008 Aug 29;1203(1):13-20. doi: 10.1016/j.chroma.2008.07.028. Epub 2008 Jul 16.