Liu Ying-Xian, Liu Yan, Xu Jin-Mei, Chen Qin, Xiong Wen
Department of Ultrasound Diagnosis, China Meitan General Hospital, Beijing 100028, P.R. China.
Department of Ultrasound Diagnosis, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China.
Oncol Lett. 2018 Aug;16(2):2215-2220. doi: 10.3892/ol.2018.8879. Epub 2018 Jun 1.
Color Doppler ultrasound and contrast-enhanced ultrasound (CEUS) in the diagnosis of lacrimal apparatus tumors were investigated. In total, 48 patients undergoing preoperative two-dimensional and color Doppler ultrasound and CEUS examinations were included in this study. Conventional ultrasound and CEUS characteristics of 48 patients pathologically and clinically diagnosed with lacrimal apparatus tumors were retrospectively analyzed. Results of conventional ultrasound of 29 cases with pleomorphic adenoma of lacrimal gland showed moderate-hypoechogenic solid masses in lacrimal gland; CEUS displayed two enhancement modes: High, fast-developed slow-extinct and overall uniform enhancement (20/29, 68.97%) and high, fast-developed slow-extinct, centripetal, uniform or non-uniform enhancement (9/29, 31.03%); after enhancement, the mass edge was clear without changes in size. Results of conventional ultrasound of 6 cases with adenoid cystic carcinoma of lacrimal gland showed hypoechogenic solid masses with unclear edge, irregular form, non-uniform echo, and abundant blood flow signals; the CEUS displayed high, fast-developed fast-extinct and overall uniform enhancement; after enhancement, mass edge was unclear and masses were larger than that in two-dimensional ultrasound. Results of conventional ultrasound of 10 cases with lacrimal sac cyst showed non-uniform, hypoechogenic masses, or cystic solid mixed masses with clear edge but no blood flow signal; the CEUS displayed peripheral circular enhancement and no enhancement inside. Results of conventional ultrasound of 3 cases with adenocarcinoma of lacrimal sac showed hypoechogenic solid masses with unclear edge, irregular form, non-uniform echo inside, and abundant blood flow signals in lacrimal sac; CEUS displayed high, fast-developed fast-extinct and overall uniform enhancement; after enhancement, masses with irregular shapes were obviously larger than that in two-dimensional ultrasound. CEUS shows the microcirculation of tumors and surrounding tissues. Combination of two-dimensional and color Doppler ultrasound can improve the preoperative qualitative diagnosis of tumors and provide references for the selection of operation methods and determination of tumor resection scope.
研究了彩色多普勒超声和超声造影（CEUS）在泪器肿瘤诊断中的应用。本研究共纳入48例术前行二维及彩色多普勒超声和CEUS检查的患者。回顾性分析48例经病理和临床诊断为泪器肿瘤患者的常规超声及CEUS特征。29例泪腺多形性腺瘤的常规超声结果显示泪腺内为中等回声偏低的实性肿块；CEUS显示两种增强模式：高增强、快速上升缓慢消退及整体均匀增强（20/29，68.97%）和高增强、快速上升缓慢消退、向心性、均匀或不均匀增强（9/29，31.03%）；增强后，肿块边缘清晰，大小无变化。6例泪腺腺样囊性癌的常规超声结果显示为低回声实性肿块，边缘不清，形态不规则，回声不均匀，血流信号丰富；CEUS显示高增强、快速上升快速消退及整体均匀增强；增强后，肿块边缘不清，肿块较二维超声显示的更大。10例泪囊囊肿的常规超声结果显示为不均匀的低回声肿块或囊实性混合肿块，边缘清晰，无血流信号；CEUS显示周边环形增强，内部无增强。3例泪囊腺癌的常规超声结果显示为低回声实性肿块，边缘不清，形态不规则，内部回声不均匀，泪囊内血流信号丰富；CEUS显示高增强、快速上升快速消退及整体均匀增强；增强后，形态不规则的肿块明显较二维超声显示的更大。CEUS可显示肿瘤及周围组织的微循环。二维和彩色多普勒超声联合应用可提高肿瘤的术前定性诊断，为手术方式的选择及肿瘤切除范围的确定提供参考。
