血栓调节蛋白基因 C1418T 多态性与中国儿童川崎病易感性的关联。
Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children.
机构信息
Department of Pediatrics, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Central Laboratory, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
出版信息
Dis Markers. 2018 Jun 12;2018:1064380. doi: 10.1155/2018/1064380. eCollection 2018.
Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children and can result in coronary artery lesions (CALs). Thrombomodulin (TM) is a critical cofactor in the protein C anticoagulant system. The C1418T (rs1042579) polymorphism is associated with a high risk of cardiac-cerebral vascular diseases. But the association of the C1418T polymorphism with susceptibility to KD, CAL formation, and intravenous immunoglobulin (IVIG) resistance is still unclear. In our study, we examined the C1418T polymorphism in 122 children with KD and 126 healthy children and revealed the correlation between the C1418T polymorphism and KD, CAL formation, and IVIG resistance.
川崎病（KD）是一种主要影响儿童的急性全身性血管炎，可导致冠状动脉损伤（CALs）。血栓调节蛋白（TM）是蛋白 C 抗凝系统的关键辅助因子。C1418T（rs1042579）多态性与心脑血管疾病的高风险相关。但是，C1418T 多态性与 KD、CAL 形成和静脉注射免疫球蛋白（IVIG）抵抗的易感性之间的关系尚不清楚。在我们的研究中，我们检测了 122 例 KD 患儿和 126 例健康儿童的 C1418T 多态性，并揭示了 C1418T 多态性与 KD、CAL 形成和 IVIG 抵抗之间的相关性。
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