Majidi Alireza, Shahhosseini Tala, Mahmoudi Sadrolla
Emergency Department, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Emergency Department, Shohadaye Pakdasht Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Emerg (Tehran). 2018;6(1):e35. Epub 2018 Jun 5.
Compared to ordinary people, addicts usually have a lower pain threshold. The current work attempts to compare the performance of local analgesia with lidocaine among opium addicts and non-addicts.
In this case-control study, opium addicts and healthy patients with skin laceration referring to emergency departments of two educational hospitals were compared regarding the response to local anesthesia with lidocaine, as well as side effects.
197 cases with the mean age of 43.44 ± 20.12 years were studied (72.1% male). 98 (49.8%) cases were addicts and 99 (50.2%) were healthy people. Two groups were similar regarding age (p = 0.281), sex (p = 0.666), and wound size (p = 0.272). The amount of pain reduction 5 (df =1.5, F=0.38, p = 0.88) and 10 (df =1.5, F=0.58, p = 0.72) minutes after lidocaine injection was not different between the groups. Subgroup analysis based on sex and age of patient did not show any differences between the groups (p > 0.1 for all analysis). The mean duration of analgesia was 16.4 ± 5.37 minutes in addicts and 16.95±1.79 in control group (p = 0.334).
Lidocaine, as a commonly used local anesthetic agents, does not show different effects in addicts and non-addicts in repairing skin laceration.
与普通人相比，成瘾者通常痛阈较低。当前研究试图比较利多卡因在阿片类成瘾者和非成瘾者中进行局部镇痛的效果。
在这项病例对照研究中，比较了两所教学医院急诊科收治的阿片类成瘾者和皮肤裂伤的健康患者对利多卡因局部麻醉的反应及副作用。
共研究了197例患者，平均年龄43.44±20.12岁（72.1%为男性）。其中98例（49.8%）为成瘾者，99例（50.2%）为健康人。两组在年龄（p = 0.281）、性别（p = 0.666）和伤口大小（p = 0.272）方面相似。利多卡因注射后5分钟（自由度=1.5，F=0.38，p = 0.88）和10分钟（自由度=1.5，F=0.58，p = 0.72）时两组的疼痛减轻程度无差异。基于患者性别和年龄的亚组分析显示两组之间无差异（所有分析p>0.1）。成瘾者的平均镇痛持续时间为16.4±5.37分钟，对照组为16.95±1.79分钟（p = 0.334）。
利多卡因作为常用的局部麻醉剂，在修复皮肤裂伤时对成瘾者和非成瘾者的效果无差异。
