Department of Pharmacology, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi, India.
Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana State, India.
Phytother Res. 2018 Oct;32(10):1908-1932. doi: 10.1002/ptr.6152. Epub 2018 Jul 15.
Heart is the most active and incumbent organ of the body, which maintains blood flow, but due to various pathological reasons, several acute and chronic cardiac complications arise out of which myocardial infarction is one of the teething problems. Isoproterenol (ISP)-induced myocardial ischemia is a classical model to screen the cardioprotective effects of various pharmacological interventions. Phytochemicals present a novel option for treating various human maladies including those of the heart. A large number of plant products and their active ingredients have been screened for efficacy in ameliorating ISP-induced myocardial ischemia including coriander, curcumin, Momordica, quercetin, and Withania somnifera. These phytochemicals constituents may play key role in preventing disease and help in cardiac remodeling. Reactive oxygen species scavenging, antiinflammatory, and modulation of various molecular pathways such as Nrf2, NFкB, p-21 activated kinase 1 (PAK1), and p-smad2/3 signaling modulation have been implicated behind the claimed protection. In this review, we have provided a focused overview on the utility of ISP-induced cardiotoxicity, myocardial ischemia, and cardiac fibrosis for preclinical research. In addition, we have also surveyed molecular mechanism of various plant-based interventions screened for cardioprotective effect in ISP-induced cardiotoxicity, and their probable mechanistic profile is summarized.
心脏是人体最活跃和最重要的器官，它维持着血液的流动，但由于各种病理原因，会出现几种急性和慢性心脏并发症，其中心肌梗死就是其中一个棘手的问题。异丙肾上腺素（ISP）诱导的心肌缺血是筛选各种药物干预的心脏保护作用的经典模型。植物化学物质为治疗各种人类疾病提供了一种新的选择，包括心脏病。大量的植物产品及其活性成分已被筛选用于改善 ISP 诱导的心肌缺血，包括芫荽、姜黄素、苦瓜、槲皮素和睡茄。这些植物化学物质成分可能在预防疾病和心脏重构方面发挥关键作用。清除活性氧、抗炎以及调节各种分子途径，如 Nrf2、NFкB、p-21 激活激酶 1（PAK1）和 p-smad2/3 信号转导，都被认为是其声称的保护作用的背后机制。在这篇综述中，我们对 ISP 诱导的心脏毒性、心肌缺血和心脏纤维化在临床前研究中的应用进行了重点概述。此外，我们还调查了筛选用于 ISP 诱导的心脏毒性的心脏保护作用的各种基于植物的干预措施的分子机制，并对其可能的机制概况进行了总结。
