Malviya Rishabha, Sharma Pramod, Dubey Susheel
Polymer Science Laboratory, Department of Pharmacy, School of Medical & Allied Sciences, Galgotias University, Greator Noida U.P., India.
Department of Pharmacy, Uttarkhand Technical University, Dehradun, India.
Polim Med. 2017 Jul-Dec;47(2):65-76. doi: 10.17219/pim/76515.
Natural polymers have been used in medical, pharmaceutical, cosmetic and food industry. They should be characterized before their possible applications in different industries.
The objective of this study was to characterize Kheri (Acacia chundra, family: Mimosaceae) gum using analytical, mathematical and pharmaceutical approaches.
Crude Kheri gum (KG) was purified using distilled water as a solvent and ethanol as a precipitating agent. KG was characterized in terms of phytochemical screening, micromeritic properties, microbial load, ash value, rheological behavior, solid state 1H nuclear magnetic resonance (NMR), mass spectra and Fourier-transform infrared spectroscopy (FTIR) studies for their possible applications in food, cosmetics and pharmaceutical industry.
Studies show that KG contains carbohydrates, while protein, fat, volatile oils, alkaloids and glycosides are absent. 1% aqueous solution of polysaccharide showed 25.58 × 103 kJ/kg activation energy and 1.39 Reynold's number. Viscosity average molecular weight of purified gum was found 1.73 × 105 D. Thermodynamic parameters, i.e., change in enthalpy ΔHv and change in enthalpy ΔHv, were found to be 12.26 × 103 kJ/mol and 24.47 kJ/mol, respectively. Mathematical approach also determined the rod shaped conformation of KG in aqueous solution. IR spectroscopic study shows the presence of free (COO-) and esterified (COO-R) carboxylic acid, ether (C-O stretching), galacturonic acid and mannose in polysaccharide 1H NMR study predicts presence of tetrahydropyran hydrogen in molecule. Furthermore, KG was also characterized as a suspending agent using paracetamol as a model drug. Flow rate, pH, particle size and settling behavior of suspensions were evaluated. Initial particle size of dispersed phase particles does not change significantly after 45 days.
From the findings of the research it can be concluded that KG can be used as an excipient in cosmaceuticals and pharmaceuticals and its characteristic rheological behavior may attract rheologists.
天然聚合物已应用于医疗、制药、化妆品和食品工业。在其可能应用于不同行业之前，应对其进行表征。
本研究的目的是采用分析、数学和制药方法对凯瑞（阿拉伯胶，含羞草科）胶进行表征。
以蒸馏水为溶剂、乙醇为沉淀剂对粗制凯瑞胶（KG）进行纯化。对KG进行了植物化学筛选、粉体学性质、微生物负荷、灰分值、流变行为、固态1H核磁共振（NMR）、质谱和傅里叶变换红外光谱（FTIR）研究，以确定其在食品、化妆品和制药工业中的可能应用。
研究表明，KG含有碳水化合物，不含蛋白质、脂肪、挥发油、生物碱和糖苷。多糖的1%水溶液显示出25.58×103 kJ/kg的活化能和1.39的雷诺数。纯化胶的粘均分子量为1.73×105 D。热力学参数，即焓变ΔHv和熵变ΔSv，分别为12.26×103 kJ/mol和24.47 kJ/mol。数学方法还确定了KG在水溶液中的棒状构象。红外光谱研究表明多糖中存在游离（COO-）和酯化（COO-R）羧酸、醚（C-O伸缩）、半乳糖醛酸和甘露糖。1H NMR研究预测分子中存在四氢吡喃氢。此外，以对乙酰氨基酚为模型药物，将KG表征为悬浮剂。评估了悬浮液的流速、pH值、粒径和沉降行为。45天后，分散相颗粒的初始粒径没有明显变化。
从研究结果可以得出结论，KG可作为化妆品和药品中的辅料，其独特的流变行为可能会吸引流变学家。
