Farooq Uzma, Malviya Rishabha, Sharma Pramod Kumar
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, India.
Polim Med. 2014 Apr-Jun;44(2):69-74.
Natural polymers are widely used as excipients in pharmaceutical formulations. They are easily available, cheap and less toxic as compared to synthetic polymers.
This study involves the extraction and characterization of kathal (Artocarpus integer) gum as a pharmaceutical excipient.
Water was used as a solvent for extraction of the natural polymer. Yield was calculated with an aim to evaluate the efficacy of the process. The product was screened for the presence of Micrometric properties, and swelling index, flow behavior, surface tension, and viscosity of natural polymers were calculated.
Using a water based extraction method, the yield of gum was found to be 2.85%. Various parameters such as flow behavior, organoleptic properties, surface tension, viscosity, loss on drying, ash value and swelling index together with microscopic studies of particles were done to characterize the extracted gum. The result showed that extracted kathal gum exhibited excellent flow properties. The gum was investigated for purity by carrying out chemical tests for different phytochemical constituents and only carbohydrates were found to be present. It had a good swelling index (13 ± 1). The pH and surface tension of the 1% gum solution were found to be 6 ± 0.5 and 0.0627 J/m2, respectively. The ash values such as total ash, acid insoluble ash, and water soluble ash were found to be 18.9%, 0.67% and 4% respectively. Loss on drying was 6.61%. The extracted gum was soluble in warm water and insoluble in organic solvents. The scanning electron micrograph (SEM) revealed rough and irregular particles of the isolated polymer.
The results of the evaluated properties showed that kathal-derived gum has acceptable pH and organoleptic properties and can be used as a pharmaceutical excipient to formulate solid oral dosage forms.
天然聚合物在药物制剂中被广泛用作辅料。与合成聚合物相比，它们易于获取、价格低廉且毒性较小。
本研究涉及提取和表征波罗蜜（面包树）胶作为药物辅料。
用水作为提取天然聚合物的溶剂。计算产率以评估该工艺的效果。对产物进行微观特性筛选，并计算天然聚合物的溶胀指数、流动行为、表面张力和粘度。
采用水基提取方法，发现胶的产率为2.85%。对提取的胶进行了各种参数测定，如流动行为、感官特性、表面张力、粘度、干燥失重、灰分值和溶胀指数，并对颗粒进行了微观研究以进行表征。结果表明，提取的波罗蜜胶表现出优异的流动性能。通过对不同植物化学成分进行化学测试来研究胶的纯度，结果发现仅含有碳水化合物。它具有良好的溶胀指数（13±1）。1%胶溶液的pH值和表面张力分别为6±0.5和0.0627 J/m²。总灰分、酸不溶性灰分和水溶性灰分的灰分值分别为18.9%、0.67%和4%。干燥失重为6.61%。提取的胶可溶于温水，不溶于有机溶剂。扫描电子显微镜（SEM）显示分离出的聚合物颗粒粗糙且不规则。
评估特性的结果表明，波罗蜜衍生的胶具有可接受的pH值和感官特性，可作为药物辅料用于制备固体口服剂型。
