1 Department of Experimental Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
2 Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Tissue Eng Part A. 2019 Jan;25(1-2):131-144. doi: 10.1089/ten.TEA.2018.0112. Epub 2018 Oct 3.
The use of chemically modified RNA (cmRNA) with increased stability using translation initiator of short untranslated regions (TISU) offers the prospect of finally allowing us to unlock the potent osteogenic properties of BMP-2 in a clinically expedient manner. As noted, delivery of recombinant BMP-2 protein has had modest clinical efficacy, whereas gene delivery is effective but very difficult to translate into human clinical use. This study shows the great potential of cmRNA encoding BMP-2 with TISU in a long-bone critical-sized rat model.
使用具有增加的稳定性的化学修饰 RNA (cmRNA) 和短非翻译区 (TISU) 的翻译起始子，为我们最终以临床适宜的方式解锁 BMP-2 的潜在成骨特性提供了可能。如前所述，重组 BMP-2 蛋白的递送具有适度的临床疗效，而基因递送是有效的，但很难转化为人类临床使用。本研究表明，在长骨临界大小大鼠模型中，cmRNA 编码具有 TISU 的 BMP-2 具有巨大的潜力。
