Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Food Chem Toxicol. 2018 Oct;120:261-276. doi: 10.1016/j.fct.2018.07.024. Epub 2018 Jul 20.
Internal metabolism and environmental toxicant exposure can be caused to generate reactive oxygen species in human organelles which lead to oxidative stress. The nuclear factor erythroid 2-related factor 2 (Nrf2), a basic leucine zipper (bZip) transcription factor, controls the expression of antioxidant response element (ARE)-dependent genes to regulate cellular resistance to oxidants. Nrf2 is an essential factor for hepatoprotection against drugs and xenobiotics. The key role of Nrf2 in hepatoprotection has been highlighted since Nrf2 knockout mice showed high sensitivity to xenobiotic-induced hepatotoxicity. Some natural products including polyphenols, terpenoids and alkaloids can induce Nrf2 expression as a key protein in the antioxidant defense system of hepatocytes. This review outlines natural product activators of Nrf2 that protect the liver from toxicity induced by xenobiotics.
内部代谢和环境毒物暴露会导致人类细胞器中产生活性氧物种，从而导致氧化应激。核因子红细胞 2 相关因子 2（Nrf2）是一种碱性亮氨酸拉链（bZip）转录因子，控制抗氧化反应元件（ARE）依赖性基因的表达，以调节细胞对氧化剂的抵抗力。Nrf2 是对抗药物和外源性化学物质的肝保护的重要因素。自 Nrf2 基因敲除小鼠对外源性化学物质诱导的肝毒性表现出高度敏感性以来，Nrf2 在肝保护中的关键作用得到了强调。一些天然产物，包括多酚、萜类化合物和生物碱，可以诱导 Nrf2 的表达，作为肝细胞抗氧化防御系统中的关键蛋白。本综述概述了 Nrf2 的天然产物激活剂，这些激活剂可保护肝脏免受外源性化学物质引起的毒性。
