Social, Cognitive and Affective Neuroscience Laboratory (SCAN Lab), Department of Psychiatry, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Social, Cognitive and Affective Neuroscience Laboratory (SCAN Lab), Department of Psychiatry, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Neuroscience. 2018 Sep 15;388:36-44. doi: 10.1016/j.neuroscience.2018.07.008. Epub 2018 Jul 19.
Considerable work in recent years has examined the relationship between cortical thickness (CT) and general intelligence (IQ) in healthy individuals. It is not known whether specific IQ variables (i.e., perceptual reasoning [PIQ], verbal comprehension IQ [VIQ], and full-scale IQ [FSIQ]) are associated with multiple cortical measures (i.e., CT, cortical volume (CV), cortical surface area (CSA) and cortical gyrification (CG)) within the same individuals. Here we examined the association between these neuroimaging metrics and IQ in 56 healthy adults. At a cluster-forming threshold (CFT) of p < 0.05, we observed significant positive relationships between CT and all three IQ variables in regions within the posterior frontal and superior parietal lobes. Regions within the temporal and posterior frontal lobes exhibited positive relationships between CV and two IQ variables (PIQ and FSIQ) and regions within the inferior parietal lobe exhibited positive relationships between CV and PIQ. Additionally, CV was positively associated with VIQ in the left insula and with FSIQ within the inferior frontal gyrus. At a more stringent CFT (p < 0.01), the CT-PIQ, CT-VIQ, CT-FSIQ, and CV-PIQ relationships remained significant within the posterior frontal lobe, as did the CV-PIQ relationship within the temporal and inferior parietal lobes. We did not observe statistically significant relationships between IQ and either CSA or CG. Our findings suggest that the neural basis of IQ extends beyond previously observed relationships with fronto-parietal regions. We also conclude that CT and CV may be more useful metrics than CSA or CG in the study of intellectual abilities.
近年来，大量研究探讨了皮质厚度（CT）与健康个体一般智力（IQ）之间的关系。目前尚不清楚特定的 IQ 变量（即感知推理 [PIQ]、言语理解 IQ [VIQ] 和全量表 IQ [FSIQ]）是否与个体的多个皮质测量值（即 CT、皮质体积 [CV]、皮质表面积 [CSA] 和皮质褶皱 [CG]）相关。在这里，我们研究了这 56 名健康成年人的这些神经影像学指标与 IQ 之间的关联。在聚类形成阈值（CFT）为 p < 0.05 时，我们观察到 CT 与后额和顶叶区域内的所有三个 IQ 变量之间存在显著的正相关关系。颞叶和额后区域内的 CV 与两个 IQ 变量（PIQ 和 FSIQ）呈正相关，顶下区域内的 CV 与 PIQ 呈正相关。此外，CV 与左侧岛叶的 VIQ 呈正相关，与下额回的 FSIQ 呈正相关。在更严格的 CFT（p < 0.01）下，CT-PIQ、CT-VIQ、CT-FSIQ 和 CV-PIQ 之间的关系在后额叶内仍然显著，颞叶和顶下区域内的 CV-PIQ 关系也是如此。我们没有观察到 IQ 与 CSA 或 CG 之间存在统计学上的显著关系。我们的研究结果表明，IQ 的神经基础超出了先前观察到的与额顶区域的关系。我们还得出结论，CT 和 CV 可能比 CSA 或 CG 更有助于研究智力能力。
