Elhami Elham, Zakeri Zahra, Sadeghi Amir, Rostami-Nejad Mohammad, Volta Umberto, Zali Mohammad Reza
Labafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gastroenterol Hepatol Bed Bench. 2018 Summer;11(3):239-243.
Patients with Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), and Fibromyalgia (FM) may have underlying non-diagnosed celiac disease (CD).
The aim of this study was to determine the prevalence of CD in patients with these underlying diseases in Iran.
This cross-sectional study was performed among 300 consecutive patients with SLE, RA, and FM (each group 100 patients) since 2015 to 2017. The blood samples were collected and serum IgA anti-tissue trans-glutaminase (Anti-tTG) level was assessed for all patients. The seropositive patients underwent endoscopy and duodenal/jejunal biopsy according to the Marsh classification.
Out of 300 investigated patients with mean age of 41.2 years old, 92% of patients with SLE, RA and fibromyalgia were women. Among 100 patients with SLE, only 1 subject (1%), out of 100 patients with RA 3 subjects (3%), and none of the patients with fibromyalgia were seropositive for CD (with overall prevalence 1.4). All four patients were female and categorized as Marsh III.
The results of the study indicated that patients with lupus have the same prevalence, but subjects with RA had three times higher prevalence rate than normal population for CD. Therefore, CD investigation in these individuals can improve their quality of life.
系统性红斑狼疮（SLE）、类风湿关节炎（RA）和纤维肌痛（FM）患者可能存在未被诊断出的乳糜泻（CD）。
本研究的目的是确定伊朗这些基础疾病患者中CD的患病率。
自2015年至2017年，对300例连续性SLE、RA和FM患者（每组100例）进行了这项横断面研究。采集所有患者的血样并评估血清IgA抗组织转谷氨酰胺酶（抗tTG）水平。血清学阳性患者根据马什分类法接受内镜检查及十二指肠/空肠活检。
在300例平均年龄为41.2岁的被调查患者中，92%的SLE、RA和纤维肌痛患者为女性。在100例SLE患者中，仅1例（1%）CD血清学阳性；100例RA患者中有3例（3%）CD血清学阳性；纤维肌痛患者中无CD血清学阳性者（总体患病率为1.4%）。所有4例患者均为女性，分类为马什III型。
研究结果表明，狼疮患者的患病率相同，但RA患者的患病率是正常人群的三倍。因此，对这些个体进行CD筛查可改善其生活质量。
