Pasternak G W, Adler B A, Rodriguez J
Postgrad Med J. 1985;61 Suppl 2:5-12.
Meptazinol is a unique opioid analgesic. Binding studies suggest a relative selectivity for mu 1 sites, as opposed to the other opioid receptor binding sites. This binding selectivity is consistent with meptazinol's supraspinal site of action and its sensitivity to the mu 1-selective opiate antagonist naloxonazine. Furthermore, at equianalgesic doses, morphine depressed respiration to a greater degree than meptazinol.
美普他酚是一种独特的阿片类镇痛药。结合研究表明，它对μ1位点具有相对选择性，与其他阿片受体结合位点不同。这种结合选择性与美普他酚的脊髓上作用部位及其对μ1选择性阿片拮抗剂纳洛嗪的敏感性相一致。此外，在等效镇痛剂量下，吗啡对呼吸的抑制作用比美普他酚更强。
