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两名接受来自Rh免疫供体肾脏移植的Rh阳性患者体内的抗Rho(D)。

Anti-Rho(D) in two Rh-positive patients receiving kidney grafts from an Rh-immunized donor.

作者信息

Ramsey G, Israel L, Lindsay G D, Mayer T K, Nusbacher J

出版信息

Transplantation. 1986 Jan;41(1):67-9. doi: 10.1097/00007890-198601000-00014.

DOI:10.1097/00007890-198601000-00014
PMID:3001981
Abstract

Kidneys from an Rh-negative cadaver donor were transplanted to two Rh-positive patients. The donor's serum contained anti-Rho (D). In both patients, anti-Rho (D) was detected in their serum and on their red cells 3.5 weeks after transplantation. One patient had hemolysis. The antibodies persisted for nearly six months, despite graft rejection and nephrectomy in one case. These antibodies presumably arose from passenger B lymphocytes in the grafts from the Rh-immunized donor.

摘要

一名Rh阴性尸体供者的肾脏被移植给了两名Rh阳性患者。供者血清中含有抗Rho(D)。两名患者在移植后3.5周时,其血清和红细胞上均检测到了抗Rho(D)。其中一名患者发生了溶血。尽管其中一名患者出现了移植排斥反应并接受了肾切除术,但这些抗体持续存在了近六个月。这些抗体大概是来自经Rh免疫的供者移植物中的过客B淋巴细胞。

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引用本文的文献

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NDT Plus. 2008 Jun;1(3):164-6. doi: 10.1093/ndtplus/sfn023. Epub 2008 Mar 27.
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Pottransplantation anemia: management and rationale.肾移植后贫血:管理与基本原理。
Clin J Am Soc Nephrol. 2008 Mar;3 Suppl 2(Suppl 2):S49-55. doi: 10.2215/CJN.03290807.
3
Red cell antibody problems in 1000 liver transplants.1000例肝移植中的红细胞抗体问题
Transfusion. 1989 Jun;29(5):396-400. doi: 10.1046/j.1537-2995.1989.29589284137.x.
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Acute hemolytic anemia in liver and bone marrow transplant patients under FK 506 therapy.接受FK 506治疗的肝和骨髓移植患者的急性溶血性贫血
Transplant Proc. 1991 Dec;23(6):3190-2.