Division of Urology, Department of Surgery, Universite de Montreal, Montreal, QC, Canada.
Division of Robotic Urology, Department of Surgery, Hôpital Sacré Coeur de Montréal, Montreal, QC, Canada.
Biomark Med. 2018 Aug;12(8):841-848. doi: 10.2217/bmm-2017-0321. Epub 2018 Jul 18.
Utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in predicting biochemical recurrence (BCR) in patients with localized prostate cancer.
MATERIALS & METHODS: Retrospective analysis of patients operated by robot-assisted radical prostatectomy. Variables included were: NLR, PLR pre-operative prostate specific antigen, pathological Gleason score, surgical margins status, extracapsular extension, seminal vesical invasion, and lymph node status.
Out of 321 patients, no association between NLR or PLR and BCR was detected. Predictors of BCR were pathological Gleason score, extracapsular extension and positive surgical margins. On multivariate analysis, the Gleason Score, extracapsular extension and positive surgical margins remained the only predictors of BCR.
Neither elevated NLR nor PLR predicted an increased risk of BCR.
中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）在预测局限性前列腺癌患者生化复发（BCR）中的作用。
对接受机器人辅助前列腺根治性切除术的患者进行回顾性分析。包括的变量有：NLR、PLR 术前前列腺特异性抗原、病理 Gleason 评分、手术切缘状态、包膜外侵犯、精囊侵犯和淋巴结状态。
在 321 例患者中，NLR 或 PLR 与 BCR 之间无相关性。BCR 的预测因子为病理 Gleason 评分、包膜外侵犯和阳性手术切缘。多因素分析显示，Gleason 评分、包膜外侵犯和阳性手术切缘仍然是 BCR 的唯一预测因子。
升高的 NLR 或 PLR 均不能预测 BCR 风险增加。
