辐射及抑制二磷酸腺苷核糖基转移酶对辐射敏感和抗性小鼠淋巴瘤（L5178Y）细胞的影响。
Effects of irradiation and inhibition of adenosine diphosphate ribosyl transferase in radiation sensitive and resistant mouse lymphoma (L5178Y) cells.
作者信息
Johanson K J, Sundell-Bergman S, Szumiel I, Wlodek D
出版信息
Acta Radiol Oncol. 1985 Sep-Oct;24(5):451-7. doi: 10.3109/02841868509134416.
The effects of treatment with benzamide, an inhibitor of adenosine diphosphate (ADP) ribosyl transferase, were studied in two strains of L5178Y lymphoma cells of differential sensitivity to ionizing radiation. Continuous 2 mmol/l benzamide treatment enhanced the killing effect of roentgen irradiation in the sensitive cells, but not in the resistent cells. Three hours' treatment with 2 to 15 mmol/l benzamide sensitized irradiated cells of both strains to a similar extent. Rejoining of DNA breaks was delayed by 2 mmol/l benzamide in sensitive cells more than in resistant cells.
研究了二磷酸腺苷（ADP）核糖基转移酶抑制剂苯甲酰胺的治疗效果，该研究选用了对电离辐射敏感性不同的两株L5178Y淋巴瘤细胞。连续用2 mmol/l苯甲酰胺处理可增强X线照射对敏感细胞的杀伤作用，但对耐药细胞无效。用2至15 mmol/l苯甲酰胺处理3小时可使两株受照射细胞的敏感性提高到相似程度。2 mmol/l苯甲酰胺使敏感细胞中DNA断裂的重新连接比耐药细胞延迟更久。
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