Nishimura Tomoyuki, Kuwai Toshio, Imagawa Hiroki, Kohno Hiroshi
Department of Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
BMJ Case Rep. 2018 Jul 18;2018:bcr-2018-224467. doi: 10.1136/bcr-2018-224467.
Jejunoileal follicular lymphomas (FLs) are rare and have been reported to undergo histological transformation (HT). We report a case of jejunoileal FL transformation into diffuse large B-cell lymphoma (DLBCL). An 82-year-old woman presented with a 5.5 cm ulcerated jejunal mass, identified through double-balloon enteroscopy. The histopathology report revealed diffuse atypical lymphoid cells, which confirmed the presence of DLBCL. Neoplastic follicles confirmed the presence of FL. Genetic analysis revealed a match between the FL and DLBCL. Following a segmentectomy and chemotherapy, the patient is in remission. Based on this case, we should consider the possibility of jejunoileal FLs transforming into DLBCL.
空肠回肠滤泡性淋巴瘤（FLs）较为罕见，据报道可发生组织学转化（HT）。我们报告一例空肠回肠FL转化为弥漫性大B细胞淋巴瘤（DLBCL）的病例。一名82岁女性通过双气囊小肠镜检查发现有一个5.5厘米的空肠溃疡性肿块。组织病理学报告显示为弥漫性非典型淋巴细胞，确诊为DLBCL。肿瘤性滤泡证实存在FL。基因分析显示FL和DLBCL相匹配。在进行节段切除和化疗后，患者处于缓解状态。基于此病例，我们应考虑空肠回肠FLs转化为DLBCL的可能性。
