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本文引用的文献

1
Call for Action: Invasive Fungal Infections Associated With Ibrutinib and Other Small Molecule Kinase Inhibitors Targeting Immune Signaling Pathways.行动呼吁：伊布替尼和其他靶向免疫信号通路的小分子激酶抑制剂相关的侵袭性真菌感染。
Clin Infect Dis. 2018 Jan 6;66(1):140-148. doi: 10.1093/cid/cix687.
2
Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma.依鲁替尼对原发性中枢神经系统淋巴瘤中B细胞受体信号传导的抑制作用
Cancer Cell. 2017 Jun 12;31(6):833-843.e5. doi: 10.1016/j.ccell.2017.04.012. Epub 2017 May 25.
3
Calcineurin Orchestrates Lateral Transfer of Aspergillus fumigatus during Macrophage Cell Death.钙调神经磷酸酶在巨噬细胞死亡过程中调控烟曲霉的横向转移。
Am J Respir Crit Care Med. 2016 Nov 1;194(9):1127-1139. doi: 10.1164/rccm.201601-0070OC.
4
Small-molecule kinase inhibitors: an analysis of FDA-approved drugs.小分子激酶抑制剂：FDA 批准药物分析。
Drug Discov Today. 2016 Jan;21(1):5-10. doi: 10.1016/j.drudis.2015.07.008. Epub 2015 Jul 23.
5
Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.布鲁顿酪氨酸激酶对于NLRP3炎性小体激活至关重要，并导致缺血性脑损伤。
Nat Commun. 2015 Jun 10;6:7360. doi: 10.1038/ncomms8360.
6
Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK.布鲁顿酪氨酸激酶（BTK）和白细胞介素-2诱导激酶（ITK）的抑制剂依鲁替尼可增强检查点阻断的治疗性抗肿瘤免疫。
Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E966-72. doi: 10.1073/pnas.1500712112. Epub 2015 Feb 17.
7
Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.吞噬作用依赖的TLR9-BTK-钙调神经磷酸酶-NFAT途径激活协调对烟曲霉的固有免疫。
EMBO Mol Med. 2015 Mar;7(3):240-58. doi: 10.15252/emmm.201404556.
8
Outcomes of patients with chronic lymphocytic leukemia after discontinuing ibrutinib.停用依鲁替尼后慢性淋巴细胞白血病患者的预后
Blood. 2015 Mar 26;125(13):2062-7. doi: 10.1182/blood-2014-09-603670. Epub 2015 Jan 8.
9
The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome.非受体酪氨酸激酶Tec控制非经典半胱天冬酶-8炎性小体的组装和活性。
PLoS Pathog. 2014 Dec 4;10(12):e1004525. doi: 10.1371/journal.ppat.1004525. eCollection 2014 Dec.
10
Bruton's tyrosine kinase inhibitors and their clinical potential in the treatment of B-cell malignancies: focus on ibrutinib.布鲁顿酪氨酸激酶抑制剂及其在治疗 B 细胞恶性肿瘤中的临床潜力：以伊布替尼为例。
Ther Adv Hematol. 2014 Aug;5(4):121-33. doi: 10.1177/2040620714539906.

伊布替尼在人巨噬细胞吞噬过程中阻断 Btk 依赖性 NF-κB 和 NFAT 反应。

Ibrutinib blocks Btk-dependent NF-ĸB and NFAT responses in human macrophages during phagocytosis.

机构信息

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Medical Research Council (MRC) Centre for Medical Mycology, University of Aberdeen, Aberdeen, United Kingdom.

出版信息

Blood. 2018 Nov 1;132(18):1985-1988. doi: 10.1182/blood-2017-12-823393. Epub 2018 Jul 18.

DOI:10.1182/blood-2017-12-823393
PMID:30021784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6450054/
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