Mulsow Jürgen
Mater Misericordiae University Hospital, Dublin, D07 R2WY, Ireland.
Ir J Med Sci. 2018 Nov;187(4):1139-1142. doi: 10.1007/s11845-018-1850-x. Epub 2018 Jul 18.
Approximately one-third of patients with Crohn's disease have a distinct fibrostenosing phenotype predisposing them to recurrent intestinal stricture formation. The intestinal fibroblast was thought to play a critical role in the abnormal wound healing which ends in stricture formation. Recognising this, a laboratory-based research study was initiated at the Mater Misericordiae Hospital and University College Dublin with the aim of investigating the key steps in intestinal fibroblast-mediated stricture pathogenesis. An in vitro model was developed using cultured fibroblasts taken from sites of stricture in patients undergoing surgery. In summary, these fibroblasts were shown to carry multiple distinct pro-fibrotic phenotypic changes which may explain the abnormal wound healing and scar formation found at their sites of origin. This paper reviews that body of work, undertaken by series of surgical researchers and scientists, and driven by the insight, guidance and mentorship of Professor Ronan O'Connell.
大约三分之一的克罗恩病患者具有明显的纤维狭窄表型，这使他们易于反复形成肠道狭窄。肠道成纤维细胞被认为在导致狭窄形成的异常伤口愈合过程中起关键作用。认识到这一点后，仁慈圣母医院和都柏林大学学院开展了一项基于实验室的研究，旨在调查肠道成纤维细胞介导的狭窄发病机制中的关键步骤。利用从接受手术患者的狭窄部位获取的培养成纤维细胞建立了一个体外模型。总之，这些成纤维细胞表现出多种不同的促纤维化表型变化，这可能解释了在其起源部位发现的异常伤口愈合和瘢痕形成。本文回顾了由一系列外科研究人员和科学家所做的那项工作，该工作由罗南·奥康奈尔教授的洞察力、指导和辅导推动。
