Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Clin Pharmacol Ther. 2018 Nov;104(5):799-802. doi: 10.1002/cpt.1185. Epub 2018 Sep 4.
Toxicity is among the greatest concerns during clinical use of drugs, and it has been well documented that transporter proteins facilitate such events by regulating drug accumulation. However, an important question is whether strategies could be adopted to diminish such toxicities. Although the field is currently in its infancy, some examples exist demonstrating how mechanistic understanding of the role of transporters in drug disposition can aid in alleviating transporter-mediated toxic effects.
毒性是药物临床应用中最令人关注的问题之一，有充分的文献记载表明转运蛋白通过调节药物蓄积来促进这些事件的发生。然而，一个重要的问题是是否可以采取策略来减少这种毒性。尽管该领域目前仍处于起步阶段，但已经有一些例子表明，对转运蛋白在药物处置中的作用的机制理解如何有助于减轻转运蛋白介导的毒性作用。
