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棕色脂肪细胞的α1-肾上腺素能激活导致肌醇多磷酸的生成增加。

Alpha 1-adrenergic activation of brown adipocytes leads to an increased formation of inositol polyphosphates.

作者信息

Nånberg E, Putney J

出版信息

FEBS Lett. 1986 Jan 20;195(1-2):319-22. doi: 10.1016/0014-5793(86)80185-5.

DOI:10.1016/0014-5793(86)80185-5
PMID:3002856
Abstract

alpha 1-Adrenergic activation of isolated brown adipocytes causes a rapid mobilization of intracellular Ca2+. The cells also respond with an increased turnover of inositol lipids. The present work demonstrates that alpha 1-adrenergic stimulation of brown adipocytes results in phospholipase C-mediated breakdown of phosphatidylinositol bisphosphate to form inositol trisphosphate. The rate of appearance of inositol trisphosphate is sufficiently rapid for it to mediate or contribute to Ca2+ mobilization in these cells.

摘要

分离的棕色脂肪细胞的α1-肾上腺素能激活会导致细胞内Ca2+迅速动员。这些细胞还会出现肌醇脂质周转率增加的反应。目前的研究表明，棕色脂肪细胞的α1-肾上腺素能刺激会导致磷脂酶C介导的磷脂酰肌醇二磷酸分解，形成肌醇三磷酸。肌醇三磷酸的出现速率足够快，足以介导或促进这些细胞中的Ca2+动员。

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1
Alpha 1-adrenergic activation of brown adipocytes leads to an increased formation of inositol polyphosphates.棕色脂肪细胞的α1-肾上腺素能激活导致肌醇多磷酸的生成增加。
FEBS Lett. 1986 Jan 20;195(1-2):319-22. doi: 10.1016/0014-5793(86)80185-5.
2
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