[Relation between adrenocorticotropic and glucocorticoid responses in the dog].

In chronic experiments on dogs, changes of adrenocorticotropic and glucocorticoid activities of blood plasma were studied under the effect of factors activating the hypothalamo-hypophyseal-adrenal system (morphine, electrical stimulation of the hypothalamus, surgical lesions). Similar as the general dynamics was, there was no complete analogy of the above two indices as the ACTH and cortisol (ACTH-activity and 17-OCS in some experiments) attain the maximal concentrations not always simultaneously, the character of changes can be opposite while in similar changes their intensity can be rather different. The data obtained disagree with the concept of exclusive dependence of the glucocorticoids secretion on the adenohypophysis. Apart from the adrenocorticotropic hormone, additional factors of extrahypophyseal origin seem to exist and affect the glucocorticoid response.