Center for Behavioral Health Research, College of Social Work, University of Tennessee, 201 Henson Hall, 1618 Cumberland Avenue, Knoxville, TN 37996-3332, United States.
Center for Behavioral Health Research, College of Social Work, University of Tennessee, 201 Henson Hall, 1618 Cumberland Avenue, Knoxville, TN 37996-3332, United States.
Addict Behav. 2018 Dec;87:151-154. doi: 10.1016/j.addbeh.2018.07.004. Epub 2018 Jul 6.
Multi-site tobacco cessation trials could benefit from remote biochemical verification for tobacco use without invasive, time-consuming, or expensive collection processes. To the authors' knowledge, there have been no previous studies examining the predictive validity of oral fluid swabs for the detection of cotinine levels with samples collected off-site and mailed for on-site interpretation.
Tobacco users were recruited through an online survey and participants who met the initial eligibility criteria were invited to take part. Those who elected to enroll provided two positive iScreen Oral Fluid Device (OFD) cotinine test samples during an in-office visit. One sample was used as a control and stored in a temperature-regulated location, while the other was mailed from one of ten surrounding counties. Mailing method and time from collection to mailing were varied, and results were assessed against control samples.
Twenty tobacco users enrolled in the study. Participants ranged in age from 18 to 31 (M = 16.45, SD = 1.54). Several types of tobacco use were reported, with electronic cigarettes the most commonly reported product. None of the mailed sample interpretations changed from pre- to post-mailing, with up to twenty-one days from sample collection to results confirmation.
Results indicate that the use of mailed oral swabs may be an easy to use, reliable, and low-cost option for the detection of cotinine in tobacco users when in-person collection is not feasible. Test result interpretations were found to be unchanged after mailing, and after extended post-collection time gaps.
多地点的戒烟试验可以受益于远程生化验证，而无需进行侵入性、耗时或昂贵的采集过程。据作者所知，此前尚无研究检验唾液拭子在检测非现场采集并邮寄进行现场解读的样本中的可替宁水平方面的预测有效性。
通过在线调查招募吸烟者，邀请符合初步入选标准的参与者参加。那些选择参加的人在办公室就诊期间提供了两份阳性 iScreen 唾液检测装置（OFD）可替宁检测样本。一份样本作为对照并储存在温度调节的位置，另一份从十个周边县中的一个县邮寄。邮寄方式和从采集到邮寄的时间有所不同，并与对照样本进行了评估。
20 名吸烟者参加了这项研究。参与者的年龄从 18 岁到 31 岁不等（M=16.45，SD=1.54）。报告了几种类型的吸烟情况，其中最常报告的产品是电子烟。邮寄样本的解释在邮寄前后都没有变化，从采集到结果确认的时间最长可达 21 天。
结果表明，当无法进行现场采集时，邮寄口腔拭子可能是一种易于使用、可靠且低成本的检测烟草使用者可替宁的选择。邮寄后，检测结果的解释不变，即使在采集后延长了时间间隔。
