Santucci A, Leonetti Luparini R, Ferri C, Ficara C, Giarrizzo C, Balsano F
J Hypertens Suppl. 1985 Nov;3(2):S133-4.
The effect of the chronic administration of captopril on plasma levels of vasopressin (PVP) were studied in 14 patients with moderate essential hypertension and 10 normal volunteers. All patients were studied after 10 days without drugs and under a constant diet (120 mmol sodium and 80 mmol potassium/day). Plasma levels of renin activity (PRA), aldosterone (PA) and PVP were assayed before and after captopril treatment (50-100 mg/day for 1 month). In addition to the well-known effect of captopril treatment on PRA and PA, a statistically significant reduction of PVP was observed. This finding suggests that the renin-angiotensin-aldosterone system influences vasopressin release, and its inhibitors may contribute to the absence of water retention during captopril treatment compared with the effect of other vasodilatory drugs.
在14例中度原发性高血压患者和10名正常志愿者中，研究了长期服用卡托普利对血浆血管加压素水平（PVP）的影响。所有患者在停药10天且饮食恒定（每天120 mmol钠和80 mmol钾）后进行研究。在卡托普利治疗（50 - 100 mg/天，持续1个月）前后测定血浆肾素活性（PRA）、醛固酮（PA）和PVP水平。除了卡托普利治疗对PRA和PA的众所周知的作用外，还观察到PVP有统计学意义的降低。这一发现表明肾素 - 血管紧张素 - 醛固酮系统影响血管加压素的释放，与其他血管扩张药物的作用相比，其抑制剂可能有助于卡托普利治疗期间不出现水潴留现象。
