a School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine , King's College London , London , United Kingdom.
b Division of Drug Delivery and Tissue Engineering, Boots Science Building , University of Nottingham , Nottingham , United Kingdom.
Expert Opin Drug Deliv. 2018 Aug;15(8):759-770. doi: 10.1080/17425247.2018.1504017. Epub 2018 Jul 27.
Research into oral delivery of biologics has a long and rich history but has not produced technologies used in the clinic. The area has evolved in terms of strategies to promote oral biologics delivery from early chemical absorption enhancers to nanomedicine to devices. Continued activity in this area is justifiable considering the remarkable proliferation of biologics.
The article discusses some physiological barriers to oral delivery of biologics, with a special focus on less characterized barriers such as the basement membrane. Recent progress in oral delivery of biologics via nanomedicine is subsequently covered. Finally, the emerging field of device-mediated gastrointestinal delivery of biotherapeutics is discussed
Oral delivery of biologics is considered a 'panacea' in drug delivery. Almost century-old approaches of utilizing chemical absorption enhancers have not produced clinically translated technologies. Nanomedicine for oral biologics delivery has demonstrated potential, but the field is relatively new, and technologies have not progressed to the clinic. Device-mediated oral biologics delivery (e.g. ultrasound or microneedles) is in its infancy. However, this space is likely to intensify owing to advances in electronics and materials, as well as the challenges and history related to clinical translation of alternative approaches.
生物制品的口服递送研究有着悠久而丰富的历史，但尚未产生用于临床的技术。该领域在促进口服生物制剂递送的策略方面不断发展，从早期的化学吸收增强剂到纳米医学再到设备。考虑到生物制剂的显著增殖，该领域的持续活动是合理的。
本文讨论了生物制品口服递送的一些生理障碍，特别关注基底膜等特征不太明显的障碍。随后介绍了通过纳米医学实现生物制品口服递送的最新进展。最后，讨论了新兴的设备介导的胃肠道生物治疗药物传递领域。
生物制品的口服递送被认为是药物递送的“万灵药”。利用化学吸收增强剂的近一个世纪的方法尚未产生临床转化的技术。用于口服生物制剂递送的纳米医学显示出了潜力，但该领域相对较新，技术尚未进展到临床阶段。设备介导的口服生物制剂递送（例如超声或微针）仍处于起步阶段。然而，由于电子和材料方面的进步，以及替代方法的临床转化相关的挑战和历史，这个领域可能会加强。
