Ramseier H, Lindenmann J
Exp Cell Biol. 1977;45(1-2):89-100. doi: 10.1159/000162859.
Cell-bound or shed T-lymphocyte receptors for alloantigens and the IgG-associated, alloantigen-recognizing principle in T alloantiserum reacted with antisera raised against those structures to form a product of antigenic recognition (PAR) in which the receptor or its equivalent took the role of 'antigen'. Formation of PAR was tested for numerous combinations of reactants and in all the process was completed within 1-2 h at 37 or 4 degrees C. Cell-bound receptors were found to be solubilized by all three forms of antisera, with the exception of an antiserum lacking anti-T-receptor activity. The data indicated that PAR might be a complex of antigen and antibody with granulotactic activity whose formation was specific.
针对同种异体抗原的细胞结合型或可溶性T淋巴细胞受体，以及T同种异体抗血清中与IgG相关的、识别同种异体抗原的原理，与针对这些结构产生的抗血清发生反应，形成抗原识别产物（PAR），其中受体或其等效物起“抗原”的作用。针对众多反应物组合测试了PAR的形成，并且在所有情况下，该过程在37℃或4℃下1至2小时内完成。发现所有三种形式的抗血清都能使细胞结合型受体溶解，但缺乏抗T受体活性的抗血清除外。数据表明，PAR可能是一种具有粒细胞趋化活性的抗原 - 抗体复合物，其形成具有特异性。
