Kuwahara O, Hirata T, Saotome K, Yanai N, Hirai T, Nishiyama Y, Komatsu H, Hirata M, Ishiwata K, Akiyama S
Gan No Rinsho. 1985 Nov;31(14):1771-5.
Multiple primary cancers were found after surgery in 80 (2.5%) of 3,154 patients with lung cancer. Patients with squamous cell carcinoma most frequently suffered from multiple primary cancers. The period up to discovery of the second primary cancers was within two years in 78.8% of the patients. Second primary cancers were most frequently observed in the lung, followed by the stomach, colon and rectum. Second primary cancers were found in the lung in 26 patients, 14 of these (53.8%) having squamous cell carcinoma. Multiple primary cancers were noted in 2.8% of 1,210 lung cancer patients who underwent stage I curative operation and 2.4% of the remaining 1,944 cases. As to prognosis, 14 patients survived for more than three years after the second primary cancers were found.
在3154例肺癌患者中，80例（2.5%）术后发现有多发原发性癌。鳞状细胞癌患者最常发生多发原发性癌。78.8%的患者发现第二原发性癌的时间在两年内。第二原发性癌最常见于肺部，其次是胃、结肠和直肠。26例患者的第二原发性癌发生在肺部，其中14例（53.8%）为鳞状细胞癌。在1210例行I期根治性手术的肺癌患者中，2.8%发现有多发原发性癌，在其余1944例患者中这一比例为2.4%。关于预后，14例患者在发现第二原发性癌后存活超过三年。
