Cameron V A, Espiner E A, Nicholls M G, MacFarlane M R, Sadler W A
Life Sci. 1986 Feb 10;38(6):553-9. doi: 10.1016/0024-3205(86)90034-2.
The role of the brain renin-angiotensin system in mediating the peripheral hormone response to acute hemorrhagic stress (15 ml/kg over 10 min) was studied in 6 sheep during an intracerebroventricular infusion (2.8 micrograms/min) of the angiotensin-converting enzyme inhibitor, captopril. When compared with control experiments the plasma ACTH and vasopressin (AVP) response to hemorrhage was markedly reduced and delayed during icv captopril, which did not affect the response of plasma angiotensin II (AII). These results suggest that the normal and rapid response in ACTH and AVP secretion accompanying hemorrhagic stress is dependent on increased brain production of AII.
在6只绵羊进行脑室内输注（2.8微克/分钟）血管紧张素转换酶抑制剂卡托普利的过程中，研究了脑肾素-血管紧张素系统在介导外周激素对急性出血应激（10分钟内15毫升/千克）反应中的作用。与对照实验相比，在脑室内注射卡托普利期间，血浆促肾上腺皮质激素（ACTH）和血管加压素（AVP）对出血的反应明显减弱且延迟，而这并不影响血浆血管紧张素II（AII）的反应。这些结果表明，出血应激时ACTH和AVP分泌的正常快速反应依赖于脑内AII生成的增加。
