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Disease-Modifying Osteoarthritis Treatment With Interleukin-1 Receptor Antagonist Gene Therapy in Small and Large Animal Models.在小动物和大动物模型中，白细胞介素-1 受体拮抗剂基因治疗对疾病修饰性骨关节炎的治疗作用。
Arthritis Rheumatol. 2018 Nov;70(11):1757-1768. doi: 10.1002/art.40668. Epub 2018 Sep 10.
2
Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model.骨关节炎的基因治疗：马模型中关节腔内自互补腺相关病毒白细胞介素-1受体拮抗剂递送的药代动力学
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3
Self-Complementary Adeno-Associated Virus-Mediated Interleukin-1 Receptor Antagonist Gene Delivery for the Treatment of Osteoarthritis: Test of Efficacy in an Equine Model.自我互补腺相关病毒介导的白细胞介素-1受体拮抗剂基因递送用于骨关节炎治疗：在马模型中的疗效测试
Hum Gene Ther Clin Dev. 2018 Jun;29(2):101-112. doi: 10.1089/humc.2017.143.
4
Arthritis gene therapy is becoming a reality.关节炎基因治疗正在成为现实。
Nat Rev Rheumatol. 2018 Jul;14(7):381-382. doi: 10.1038/s41584-018-0009-5.
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Gene Delivery to Joints by Intra-Articular Injection.关节内注射递送至关节的基因。
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Safety and biodistribution assessment of sc-rAAV2.5IL-1Ra administered via intra-articular injection in a mono-iodoacetate-induced osteoarthritis rat model.关节内注射 sc-rAAV2.5IL-1Ra 在单碘乙酸诱导的骨关节炎大鼠模型中的安全性和生物分布评估。
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Progress in intra-articular therapy.关节内治疗进展。
Nat Rev Rheumatol. 2014 Jan;10(1):11-22. doi: 10.1038/nrrheum.2013.159. Epub 2013 Nov 5.
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Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis.亲和素作为一种电荷驱动输送进入软骨的模型，用于治疗早期创伤后骨关节炎的药物输送。
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9
Arthritis gene therapy and its tortuous path into the clinic.关节炎基因治疗及其坎坷的临床之路。
Transl Res. 2013 Apr;161(4):205-16. doi: 10.1016/j.trsl.2013.01.002. Epub 2013 Jan 29.
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Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis.两名类风湿关节炎患者关节内基因治疗的临床反应。
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Editorial: Arthritis Gene Therapy Using Interleukin-1 Receptor Antagonist.

作者信息

Evans Christopher

机构信息

Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, Minnesota.

出版信息

Arthritis Rheumatol. 2018 Nov;70(11):1699-1701. doi: 10.1002/art.40675.

DOI:10.1002/art.40675
PMID:30035385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6203597/
Abstract
摘要