铁催化环合亚砜亚胺法合成三维杂环化合物
Three-Dimensional Heterocycles by Iron-Catalyzed Ring-Closing Sulfoxide Imidation.
作者信息
Yu Hao, Li Zhen, Bolm Carsten
机构信息
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany.
出版信息
Angew Chem Int Ed Engl. 2018 Sep 10;57(37):12053-12056. doi: 10.1002/anie.201804284. Epub 2018 Aug 17.
PMID:30035862
Abstract
A general and atom-economical method for the synthesis of cyclic sulfoximines by intramolecular imidations of azido-containing sulfoxides using a commercially available Fe phthalocyanine (Fe Pc) as catalyst has been developed. The method conveys a broad functional group tolerance and the resulting three-dimensional heterocycles can be modified by cross-coupling reactions.
摘要
已开发出一种通用且原子经济的方法，用于通过使用市售的铁酞菁（Fe Pc）作为催化剂，对含叠氮基的亚砜进行分子内酰亚胺化反应来合成环状亚砜亚胺。该方法具有广泛的官能团耐受性，并且所得的三维杂环可以通过交叉偶联反应进行修饰。
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