Bomzon A, Better O S, Blendis L M
Nephron. 1986;42(3):258-61. doi: 10.1159/000183677.
Alpha 1-Adrenoreceptor affinity constants (KD) and receptor numbers (Bmax) were determined in the kidneys of 3-day-old bile-duct-ligated (BDL) jaundiced rats using 3H-prazosin. The results were compared to 3-day-old pair-fed and nonpair-fed sham-operated rats as well as nonoperated rats as controls. Abdominal surgery (sham and BDL) resulted in a tendency towards a decrease in KD in all three groups of rats compared to nonoperated controls. The Bmax was also increased in the sham-operated groups compared to the nonoperated controls. In contrast, the tendency for a rise in the Bmax in the BDL group was significantly smaller than the rise seen in the two sham-operated groups. In summary, obstructive jaundice suppresses the normal renal alpha 1-adrenoreceptor response to abdominal surgery in the rat.
使用³H-哌唑嗪测定了3日龄胆管结扎（BDL）黄疸大鼠肾脏中的α1-肾上腺素受体亲和常数（KD）和受体数量（Bmax）。将结果与3日龄配对喂养和非配对喂养的假手术大鼠以及未手术大鼠作为对照进行比较。与未手术对照组相比，腹部手术（假手术和BDL）导致所有三组大鼠的KD均有下降趋势。与未手术对照组相比，假手术组的Bmax也有所增加。相比之下，BDL组Bmax升高的趋势明显小于两个假手术组。总之，梗阻性黄疸抑制了大鼠肾脏对腹部手术的正常α1-肾上腺素受体反应。
