Rivier C, Rivier J, Vale W
Science. 1986 Feb 7;231(4738):607-9. doi: 10.1126/science.3003907.
In the adult castrated male rat, exposure to inescapable, intermittent electroshocks inhibited the pulsatile pattern of luteinizing hormone release and markedly lowered its plasma concentrations. The central administration of the corticotropin-releasing factor (CRF) antagonist alpha-helical ovine CRF residues 9 to 41 reversed the inhibitory action of stress. Neither its peripheral injection, nor the intraventricular injection of the inactive CRF analog des-Glu to Arg ovine CRF was effective. These results suggest that endogenous CRF may mediate some deleterious effects of noxious stimuli on reproduction.
在成年去势雄性大鼠中，暴露于不可逃避的间歇性电击会抑制促黄体生成素释放的脉冲模式，并显著降低其血浆浓度。促肾上腺皮质激素释放因子（CRF）拮抗剂α-螺旋羊CRF 9至41位残基的中枢给药可逆转应激的抑制作用。其外周注射或脑室注射无活性的CRF类似物去谷氨酸-精氨酸羊CRF均无效。这些结果表明，内源性CRF可能介导有害刺激对生殖的一些有害影响。
