Coggeshall J, Merrill W, Hande K, Des Prez R
Am J Med. 1986 Feb;80(2):325-8. doi: 10.1016/0002-9343(86)90035-5.
This study had two objectives. The first was to determine if hypercalcemia presents as an isolated finding in patients with lung cancer prior to the development of abnormalities on chest radiography. The second was to correlate the presence of hypercalcemia with survival after surgical therapy. A review of clinical material over a seven-year period yielded 67 patients with diagnoses of hypercalcemia and lung cancer. No patient presented with surgically curable lung cancer associated with hypercalcemia. A review of the literature disclosed only four cases in which a putative cure occurred in the presence of hypercalcemia. Review of the clinical material and the literature revealed no instance in which hypercalcemia per se led to the diagnosis of clinically occult lung cancer. Hypercalcemia was almost always associated with large tumor masses. Median survival after the discovery of hypercalcemia complicating carcinoma of the lung was one month.
本研究有两个目标。第一个目标是确定在胸部X线检查出现异常之前，高钙血症是否作为肺癌患者的一个孤立发现出现。第二个目标是将高钙血症的存在与手术治疗后的生存率相关联。对七年期间的临床资料进行回顾，发现67例诊断为高钙血症和肺癌的患者。没有患者表现为与高钙血症相关的可手术治愈的肺癌。对文献的回顾仅发现4例在存在高钙血症的情况下实现推定治愈的病例。对临床资料和文献的回顾显示，没有实例表明高钙血症本身导致临床隐匿性肺癌的诊断。高钙血症几乎总是与大的肿瘤块相关。发现高钙血症并发肺癌后的中位生存期为1个月。
