Nakazawa T, Umegae Y, Matsui S, Yoshie Y, Fueki R, Kobayashi S
Ann Allergy. 1986 Jan;56(1):67-71.
To observe possible changes in adrenal function during asthmatic attacks due to allergen inhalation, plasma cortisol levels were measured serially in asthmatic patients who showed immediate asthmatic responses, late asthmatic responses, and dual asthmatic responses were compared with their diurnal levels. There were slightly different patterns of cortisol responses among these groups. In the five patients who showed late asthmatic responses alone, cortisol levels fell significantly during late-type attacks although the decrease was quantitatively small. In the six patients who showed immediate asthmatic responses alone, cortisol levels tended to increase slightly during immediate-type attacks. Cortisol levels in the group with dual asthmatic responses increased slightly during immediate attacks and significantly decreased during late-type attacks, although the decrease was also small.
为观察因吸入变应原导致哮喘发作期间肾上腺功能可能出现的变化，对表现出速发哮喘反应、迟发哮喘反应和双重哮喘反应的哮喘患者连续测量血浆皮质醇水平，并将其与昼夜水平进行比较。这些组之间皮质醇反应模式略有不同。在仅表现出迟发哮喘反应的5例患者中，尽管下降幅度在数量上较小，但在迟发型发作期间皮质醇水平显著下降。在仅表现出速发哮喘反应的6例患者中，在速发型发作期间皮质醇水平往往略有升高。双重哮喘反应组的皮质醇水平在速发发作期间略有升高，在迟发型发作期间显著下降，尽管下降幅度也较小。
